Original scientific paper

Met-Enkephalin Effects on Histamine-Induced Bronchoconstriction in Guinea Pigs

Dorian Tješić-Drinković
Nikola Štambuk
Duška Tješić-Drinković
Paško Konjevoda
Nikola Gotovac
Tihomir Ćurković
Ana Votava-Raić

Abstract

We investigated the effects of the neuropeptide met-enkephalin on histamine-induced bronhoconstriction in an experimental model of asthma. Classic Konzett and Rössler’s method of whole body plethysmography modified by Gjuriš, was applied in the study. This method represents a standard experimental model of bronchoconstriction, suitable
for the evaluation of peptide effects on the histamine-induced bronchoconstriction. The results of the measurements implicate a dose-related modulatory effect of met-enkephalin on the bronchoconstrictor action of histamine. Met-enkephalin doses of 1 mg/kg and 10 mg/kg, respectively, caused statistically significant reduction of the histamine-induced
bronchoconstriction. Estimated ED50 dose was 0.235 mg/kg. Further studies are needed to define practical and therapeutical use of the presented observations in respiratory pharmacology.

Keywords

met-enkephalin; bronhoconstriction; histamine; asthma; plethysmography

Hrčak ID:

5330

URI

https://hrcak.srce.hr/5330

Publication date:

15.12.2005.

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