Conference paper

VENLAFAXINE – QUETIAPINE COMBINATION IN THE TREATMENT OF COMPLICATED CLINICAL PICTURE OF ENDURING PERSONALITY CHANGES FOLLOWING PTSD IN COMORBIDITY WITH PSYCHOTIC DEPRESSION

Paola Presečki ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
Mate Mihanović ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
ante Silić ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
Ana Lončar Vuina ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
S. Caratan ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia

Abstract

PTSD is a complex disorder, which frequently occurs in comorbidity with anxious disorder, personality disorder, addiction or substance abuse disorder, depressive disorder with or without psychotic symptoms and psychotic disorder. PTSD symptoms may result from deregulation of several different neurotransmitter systems. Pharmacotherapy of PTSD depends on clinical features and
the presence of comorbid disorders. Pharmacotherapy of PTSD involves use of anxiolytics, adrenergic receptor antagonists, antidepressants, anticonvulsants and novel antipsychotics. Serotoninergic effect of antidepressants is not only effective in treating depression, but also appears to be helpful in PTSD treatment, particularly in reduction of intrusive symptoms, emotional reactivity, impulsiveness, aggression and suicidal ideation. Anypsychotics with serotoninergic-dopaminergic antagonism are being prescribed often in treatment of psychotic depression, while in PTSD treatment they are proved to be efficient in relieving intrusive symptoms and nightmares. Quetiapine as serotoninergic-dopaminergic antagonist is efficient in treatment of chronic insomnia as well as inreduction of aggressiveness. Considering PTSD refractoriness to therapy, high incidence of comorbidity and significant functional impairment, it is important to search for new psychopharmacological combinations in order to improve mental status of the patient. The paper presents 46 years old male patient with the diagnosis of Enduring personality changes following war PTSD (F62.0) in comorbidity with Recurrent depressive disorder with psychotic symptoms (F33.3), who was treated with combination of venlafaxine and quetiapine.

Keywords

enduring personality changes; PTSD; pharmacotherapy; venlafaxine - quetiapine

Hrčak ID:

55869

URI

https://hrcak.srce.hr/55869

Publication date:

30.6.2010.

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