Conference paper

COGNITIVE IMPAIRMENT AND GENERAL ANAESTHESIA Case report

Paola Presečki ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
Mate Mihanović ; Psychiatric Hospital Sveti Ivan, Jankomir 11, HR-10090 Zagreb, Croatia
Ninoslav Mimica ; Psychiatric Hospital Vrapče, Bolnička cesta 32, HR-10090 Zagreb, Croatia, School of Medicine, University of Zagreb, Šalata 3b, HR-10000 Zagreb, Croatia

Abstract

Degeneration of cholinergic receptors causes memory disorders and irreversible impairment in cognitive functions, whose advancement can lead to clinically recognizable Alzheimer’s disease (AD). Very often, the first symptoms of AD are mood swings and hence depression should be excluded by differential diagnosis since it can also cause memory disorders and cognitive deficits. Due to the characteristic clinical picture of AD, its diagnosis should not be a problem, except at the very beginning of the disease. Many AD patients are never diagnosed and therefore are not adequately treated in clinical practice. Agents used for general anaesthesia reduce cholinergic transmission, which is manifested by loss of consciousness, pain, voluntary movements and memory. In patients with compromised memory and cognitive functionality, general anaesthesia can postoperatively have an adverse effect on the prognosis of degenerative cerebral disease.
A patient is described whose preoperative impaired memory and cognitive functioning deteriorated after general anaesthesia and
whose clinical picture reached the extent of AD.

Keywords

cognitive impairment; Alzheimer's disease; aetiology; cholinergic receptors; general anaesthetics; diagnosis

Hrčak ID:

55888

URI

https://hrcak.srce.hr/55888

Publication date:

30.6.2010.

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