Review article
Diabetic nephropathy
Božidar Vujičić
; Zavod za nefrologiju i dijalizu, Klinika za internu medicinu, KBC Rijeka
Tamara Turk
; Zavod za endokrinologiju, dijabetes i bolesti metabolizma, Klinika za internu medicinu, KBC Rijeka
Željka Crnčević-Orlić
; Zavod za endokrinologiju, dijabetes i bolesti metabolizma, Klinika za internu medicinu, KBC Rijeka
Gordana Đorđević
; Zavod za Patologiju i patološku anatomiju, Medicinski fakultet u Rijeci
Sanjin Rački
; Zavod za nefrologiju i dijalizu, Klinika za internu medicinu, KBC Rijeka
Abstract
Diabetes mellitus is the most common cause of chronic renal failure in the world.
There appears to be different pathogenetic, hemodynamic and metabolic processes leading
to the pathologic mechanisms in diabetic nephropathy. In recent years, great progress has
been made in understanding the risk factors and pathogenetic processes in diabetic nephropathy.
In addition, new insight into the pathophysiology of this chronic disease has lead to
better preventive therapies, treatment possibilities and reduced progression to end stage
renal disease.
This review aims to give an overview of the pathology, diagnosis and treatment possibilities
of diabetic nephropathy. We give insights into the mechanisms leading to pathological
changes in the kidney and clinical parameters associated with these alterations, which allow
reliable characterization of the stages of kidney disease and the subsequent choice of treatment
strategy. Furthermore, we describe recent developments in the prevention and treatment
of diabetic nephropathy targeting the main risk factors, resulting in renal protection
and reduced disease progression. Finally, we address how treatment of diabetic nephropathy
affects other diabetes associated diseases, and how it reduces overall and cardiovascular
mortality in diabetic patients
Keywords
chronic renal failure; diabetes; diabetic nephropathy; microalbuminuria; RAAS inhibitors
Hrčak ID:
63060
URI
Publication date:
8.12.2010.
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