Short communication, Note

Genetic analysis of Y-chromosome microdeletions in men with a clinical diagnosis of schizophrenia

Tin Nadarević ; Department of biology and medical genetics, Faculty of medicine, University of Rijeka, Croatia
Alena Buretić-Tomljanović orcid.org/0000-0002-9840-1245 ; Department of biology and medical genetics, Faculty of medicine, University of Rijeka, Croatia

Abstract

Aim: Fertility rate of patients with schizophrenia is lower than in the general population.
The contributing factors are sex, marital status, reproductive age, socioeconomic,
cultural, and genetic factors. In this work, we tested the possible genetic association between
schizophrenia and lower fertility rate of male patients. Patients and methods: DNA
samples taken from 105 male patients with clinical diagnosis of schizophrenia (according to
DSM-IV criteria) and 100 control men were analysed for the presence of chromosome Y
azoospermia factor (AZF) microdeletions. Six sequence tagged sites (STS) spanning AZFa-c
region were analysed using two multiplex polymerase chain reactions: sY84, sY127, sY254,
and sY86, sY134, sY255. STS-marker sY14 (Yp) and pseudoautosomal locus ZFX/ZFY were
used as control loci in both reactions. Results: No evidence of AZF-microdeletions were
found in both groups. Conclusion: Microdeletions of the chromosome Y AZF-region do not
contribute to the risk or reduced fertility rate in males with schizophrenia.

Keywords

azoospermia factor; male fertility; schizophrenia

Hrčak ID:

66100

URI

https://hrcak.srce.hr/66100

Publication date:

7.3.2011.

Article data in other languages: croatian

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