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Hemodynamic effects of epidural lidocaine vs lidocaine-adrenaline in dogs

Dražen Vnuk ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Višnja Nesek-Adam ; Clinic for Anaesthesiology, Resuscitation and Intensive care, Sveti Duh General Hospital, Zagreb, Croatia
Marko Pećin ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Andrija Musulin ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Nikša Lemo ; Clinic of Internal Medicine; Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Nataša Brajenović ; Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia
Irena Brčić Karaconji ; Analytical Toxicology and Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia
Berislav Radišić ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ozren Smolec ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marija Lipar ; Clinic for Surgery, Orthopaedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia

Sažetak

Adrenaline is often added to local anaesthetic solutions to minimize and slow the systemic absorption of local anaesthetics, and thus reduce the possibility of adverse effects of these drugs and to prolong duration of action. The authors compared the effects of epidural anaesthesia with lidocaine and lidocaine-adrenaline mixture on hemodynamic changes and lidocaine serum concentrations in dogs. A total of 10 dogs of both sexes were included in study. The animals were randomly divided into one of the two groups: the lidocaine group (Group L, n5) receiving 2% lidocaine 3.3 mg/kg and the second group (Group LA, n = 5) receiving 2% lidocaine solution containing adrenaline in the same dose and volume. Lidocaine serum concentrations and hemodynamic changes associated with epidural block were recorded at 5, 15, 30, 45 and 60 minutes after local anaesthetic administration. The associated changes in respiratory rates (RR), partial pressure of carbon dioxide (PaCO2),
pH and body temperature were also noted. Statistical analysis was performed for both inter-group and in-group comparisons of parameters. Heart rate and cardiac output increased significantly in Group LA compared to baseline values. Arterial and pulmonary artery pressure decreased significantly in Group L with significant differences between the groups for the changes in these parameters. The mean serum concentrations of lidocaine were lower in Group LA compared to Group L at all times after administration. Addition of adrenaline to epidural lidocaine is associated with positive effects of adrenaline in preventing hypotension. However, because of the potential hazards of increase in heart rate and cardiac output especially in elderly and critical ill patients, the routinely use of epidurally adrenaline should be reconsidered in patients with high hemodynamic risk.

Ključne riječi

lidocaine; lidocaine-adrenaline combination; epidural anaesthesia

Hrčak ID:

72959

URI

https://hrcak.srce.hr/72959

Datum izdavanja:

20.10.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.982 *