Liječnički vjesnik, Vol. 133 No. 7-8, 2011.
Pregledni rad
DRUG INDUCED ALLERGIC INTERSTITIAL NEPHRITIS
Krešimir Galešić
Ingrid Prkačin
Miroslav Tišljar
Ivica Horvatić
Danica Galešić Ljubanović
Sažetak
The allergic interstitial nephritis (AIN) is a rare renal disorder which is commonly clinically presented with an acute renal failure. AIN is the most frequent result of the hypersensitivity related to drugs (most often antibiotics). In the patients with clinical suspicion to a drug related AIN, kidney biopsy is the most important diagnostic procedure. Except of causative drug discontinuation, AIN therapy is based on high dose glucocorticoids 1 mg/kg/day with dose tapering during consecutive 3 months. In the present work, we have shown 10 patients with drug induced AIN. We identified 4 causative drug groups among which most frequent were antibiotics. In clinical presentation of our patients acute renal failure was dominant and median of baseline serum creatinine was 497.5 µmol/L. In all patients the kidney biopsy was performed and nine patients (90%) have been treated with recommended glucocorticoid regimen, additionally, in 3 patients hemodialysis was introduced. In all patients, reduction in serum creatinine value was achieved with serum creatinine median of 152 µmol/L after a three-month glucocorticoid treatment (p=0.018).
Ključne riječi
Nephritis, interstitial – chemically induced, pathology, drug therapy; Acute kidney injury – chemically induced; Glucocorticoids – therapeutic use; Drug hypersensitivity – complications
Hrčak ID:
171842
URI
Datum izdavanja:
31.8.2011.
Posjeta: 2.640 *