Acta clinica Croatica, Vol. 58. No. 4., 2019.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2019.58.04.05
Factors Contributing to Chronic Urticaria/Angioedema and Nummular Eczema Resolution – Which Findings are Crucial?
Liborija Lugović-Mihić
orcid.org/0000-0001-7494-5742
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Iva Bukvić
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Vedrana Bulat
orcid.org/0000-0001-7415-991X
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Iva Japundžić
orcid.org/0000-0002-7544-0372
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Compared to controls, CU patients had a significantly higher prevalence of
positive Helicobacter (H.) pylori findings (p=0.020), confirmed allergies (p=0.006), increased IgE (p=0.011) and pathologic thyroid findings (p=0.049), whereas nummular eczema patients only had significantly higher positive H. pylori findings (p=0.046). Meaningful regression of both dermatoses was recorded after treatment of associated diseases, with significant benefit from H. pylori treatment. This indicated that the diagnosis of associated infections (particularly H. pylori and urogenital infections), confirmed allergies, endocrine disorders (particularly of thyroid gland in CU patients) and serum malignancy markers could play a crucial role, as their treatment may improve disease outcomes.
Ključne riječi
Chronic urticaria; Diagnostic techniques and procedures; Eczema; Helicobacter pylori; Skin diseases; Croatia
Hrčak ID:
235116
URI
Datum izdavanja:
1.12.2019.
Posjeta: 1.732 *