Izlaganje sa skupa
ROLE OF GUT MICROBIOTA IN THE INTERACTION BETWEEN IMMUNITY AND PSYCHIATRY: A LITERATURE REVIEW
Thomas Dubois
; Université Catholique de Louvain, Psychosomatics Unit, Mont-Godinne University Hospital, Yvoir, Belgium
Christine Reynaert
; Université Catholique de Louvain, Psychosomatics Unit, Mont-Godinne University Hospital, Yvoir, Belgium
Denis Jacques
; Université Catholique de Louvain, Psychosomatics Unit, Mont-Godinne University Hospital, Yvoir, Belgium
Lepiece Brice
; Université Catholique de Louvain, Psychosomatics Unit, Mont-Godinne University Hospital, Yvoir, Belgium
Nicolas Zdanowicz Zdanowicz
; Université Catholique de Louvain, Psychosomatics Unit, Mont-Godinne University Hospital, Yvoir, Belgium
Sažetak
Background: Psychiatric disorders may be correlated with a low-grade systemic inflammation but the origin of this inflammatory
response remains unclear and both genetics and environmental factors seems to be concerned. Recent researches observed
that gut microbiota seems to have an impact on the brain and immune processes.
Method: We review recent literature to a better understanding of how microbiota interacts with brain, immunity and psychiatric
disorders. We search on Pubmed, PsycINFO, PsycARTICLES and Sciencedirect articles with the keywords ”gastrointestinal microbiota”
and “mental disorders” or “psychological stress”.
Results: We showed links between gut microbiota and brain-gut axis regulation, immune and endocrine system activity,
neurophysiological changes, behavior variations and neuropsychiatric disorders. Communications between brain and gut are
bidirectional via neural, endocrine and immune pathway. Microbiota dysbiosis and increase gut permeability with subsequent
immune challenges seems to be the source of the chronic mild inflammation associated with neuropsychiatric disorders. Repeated
immune or stress events early in life may lead to neurodevelopmental disorders or sickness behavior later in life.
Conclusions: psychological stress impact gut microbiota with subsequent immune activation leading to neurodevelopmental
disorders or sickness behavior and altering neurophysiology and reactivity to stress or lifestyle.
Ključne riječi
microbiota; psychological stress; psychiatric disorder; immunity
Hrčak ID:
264120
URI
Datum izdavanja:
4.9.2019.
Posjeta: 673 *