Pregledni rad

Psychosurgery – use of deep brain stimulation for depression

Klara Labaš ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Antonia Lovrenčić ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska

Sažetak

Major depressive disorder (MDD) is a prevalent neuropsychiatric condition with significant implications for one's well-being. Despite advancements in conventional treatments, a substantial portion of patients experience treatment-resistant depression (TRD). The historical evolution of psychosurgery, from ancient trepanation to the controversial lobotomy era, lead to skepticism and criticism of the methods. However, MDD's severe and chronic nature, often refractory to standard therapies, has yet again spurred interest into psychosurgery. This time, the focus is turned to a new psychosurgical technique – deep brain stimulation (DBS). Targeting the cortico-striato-thalamo-cortical mood circuit, DBS involves precise electrode implantation to modulate dysfunctional brain circuits. DBS is a less invasive and reversible technique, representing progress over historical lesioning methods. Potential ethical concerns and risks of implementing this new psychosurgical procedure necessitate thorough regulation, controlled trials, and informed consent to ensure safety and efficacy. Despite what was previously stated, the evolving landscape of neuropsychiatric interventions brings hope for individuals contending with the significant impact of TRD and holds an exciting potential for challenges in treating TRD.

Ključne riječi

deep brain stimulation; lobotomy; major depressive disorder; psychosurgery; treatment-resistant depressive disorder

Hrčak ID:

353442

URI

https://hrcak.srce.hr/353442

Datum izdavanja:

20.12.2024.

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