Pregledni rad

Diarylamidines: Design, Interaction with DNA and Biological Activity Departments

I. Stolić ; Zavod za kemiju i biokemiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska
M. Bajić ; Zavod za kemiju i biokemiju, Veterinarski fakultet, Sveučilište u Zagrebu, Zagreb, Hrvatska

Sažetak

Diarylamidines are a group of biologically active compounds that are more than half a century used for treatment of parasitic diseases. Although the biological mechanism of action has not yet been fully explained it was found that the biological activity of compounds of this class is based on their binding in a small groove of DNA. Therefore, the compounds of this class, originally developed for the purpose of finding parasitic drugs, over time are recognized as potential drugs with broad application (e. g. anti-HIV opportunistic infections or tumours) based on their interaction with DNA - the primary genetic material. The occurrence of resistance and some associated adverse consequences prompted the research and development of new effective drugs and finding their mechanism of action at the molecular level. In the first part of this work, basic concepts are given accompanied by selected examples of this class of compounds.

Ključne riječi

Diarylamidines; small groove of DNA; biological activity

Hrčak ID:

67422

URI

https://hrcak.srce.hr/67422

Datum izdavanja:

5.5.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.550 *