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The effects of Trypanosoma brucei infection on post-partum uterine involution.

Izuchukwu S. Ochiogu ; Department of Veterinary Obstetrics and Reproductive Diseases, University of Nigeria, Nsukka. Enugu State, Nigeria.
Chukwuka N. Uchendu ; Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka. Enugu State, Nigeria.
John I. Ihedioha ; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka. Enugu State, Nigeria
Shodeinde V. O. Shoyinka ; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka. Enugu State, Nigeria
Chike F. Oguejiofor ; Department of Veterinary Obstetrics and Reproductive Diseases, University of Nigeria, Nsukka. Enugu State, Nigeria.
Chibueze K. Ike ; Department of Veterinary Obstetrics and Reproductive Diseases, University of Nigeria, Nsukka. Enugu State, Nigeria.
Edwin O. Onuoha ; Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka. Enugu State, Nigeria

Sažetak

This study investigated the effects of Trypanosoma brucei infection on post-partum (PP) uterine involution in the albino rat (Rattus norvegicus). Ninety-six rats (80 females and 16 males) were used for the study. The females were divided into 2 equal groups of 40 infected and 40 uninfected. The males which were uninfected were used for mating with the females. From each of the 2 female groups, 5 were humanely sacrifi ced daily from day 0 to day 7 PP. Body mass (BM), uterine mass (UM), uterine mass as a percentage of body mass (UMPBM), uterine histomorphology, packed cell volume (PCV), level of parasitaemia (LOP) and rectal temperature (RT) were evaluated in the females. Results showed that both the UM and the UMPBM of the infected rats were significantly higher (P<0.01) than those of the uninfected between days 1 and 7 PP. Uterine histomorphology showed that between days 3 and 7 PP, involution was more advanced in the uninfected group. Uterine sections of the infected rats had more glands, which were also larger in size. Endometrial stroma was less cellular in the uninfected rats and the myometrium showed higher nuclei density for myofi brils, which suggests some loss of cytoplasm. The PCV of the infected rats was significantly lower than that of the uninfected (P<0.01) between days 9 and 14 post-infection (PI), while the RT of the infected rats was significantly higher (P<0.01) than that of the uninfected between days 5 and 14 PI. It was therefore concluded that T. brucei infection led to a significant delay in PP uterine involution, as evidenced by the higher UM and UMPBM, and the uterine histomorphological findings in the infected rats.

Ključne riječi

Trypanosoma brucei infection; albino rat; post-partum uterine involution

Hrčak ID:

97128

URI

https://hrcak.srce.hr/97128

Datum izdavanja:

11.2.2013.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.578 *