Stručni rad
ACUTE AND CHRONIC HUMAN MYCOTOXICOSES
Maja Peraica
; Institut za medicinska istraživanja i medicinu rada, Ksaverska cesta 2, Zagreb, Hrvatska
Dubravka Rašić
; Institut za medicinska istraživanja i medicinu rada, Ksaverska cesta 2, Zagreb, Hrvatska
Sažetak
Mould toxins, also called mycotoxins, are frequently found in food and feed throughout the world. Mycotoxin exposure can be harmful to human health in various ways, causing not only toxic effects called mycotoxicoses, but also carcinogenic, genotoxic and mutagenic effect. High concentrations of mycotoxins cause acute mycotoxicoses,
frequent in tropical countries where conditions for the growth of moulds and the production of mycotoxins are favourable. In countries with a mild climate, large-scale acute mycotoxicoses are rare nowadays, although they had decimated the population of Europe several times during the course of history. Chronic mycotoxicoses are also
more frequent in tropical countries. The role of a single mycotoxin in the aetiology of a mycotoxicosis is usually difficult to prove, because humans and animals are mainly exposed to mixtures of mycotoxins. In temperate zones, as well as in Croatia, humans are frequently exposed to fumonisin B1 (FB1), ochratoxin A (OTA) and zearalenone
(ZEA), while exposure to aflatoxin B1 (AFB1) is much less frequent. Animal studies have proven that the target organ for AFB1 toxicity is the liver; for OTA, the kidneys; and for ZEA, the reproductive system. The target organ of FB1 toxicity varies among animal species, making it difficult to predict which organ could be the target in case of human
exposure. Human exposure to AFB1 causes liver malignancies, while according to studies on animals, FB1 and OTA could also be human carcinogens. This paper describes the symptoms of acute and chronic toxicity from AFB1, FB1, OTA and ZEA caused by continuous exposure of humans and animals to caused by food and feed contamination.
Ključne riječi
aflatoxin B1; fumonisin B1; mycotoxins; mycotoxicoses; ochratoxin B1; zearalenone
Hrčak ID:
101426
URI
Datum izdavanja:
25.4.2013.
Posjeta: 2.789 *