Pregledni rad

Sex hormones, immune disorders, and inflammatory rheumatic diseases

Dušanka Martinović Kaliterna ; Klinički odjel za reumatologiju i imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Dijana Perković ; Klinički odjel za reumatologiju i imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Mislav Radić ; Klinički odjel za reumatologiju i imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Daniela Marasović Krstulović ; Klinički odjel za reumatologiju i imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Katarina Borić ; Klinički odjel za reumatologiju i imunologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Split, Split, Hrvatska
Ivanka Marinović ; Zavod za fizikalnu medicinu i rehabilitaciju s reumatologijom, Klinički bolnički centar Split, Split, Hrvatska

Sažetak

It is a well-documented fact that sex hormones are implicated in the immune response and that androgens and estrogens modulate susceptibility and progression of autoimmune rheumatic diseases. Estrogens are considered to stimulate cell proliferation and humoral immune responses while androgens exert suppressive effects on both humoral and cellular immune responses. Autoimmune diseases are common in females, especially during the generative period, the most representative of estrogen-related autoimmune diseases being systemic lupus erythematosus. Estrogens and androgens are involved in the pathogenesis of the disease; both exogenous and endogenous estrogens are strong stimulators of cytokine production and disease activity. Some physiological conditions, as well as some drugs and chronic stress, can modulate hormone levels. Low levels of gonadal androgens have been detected in body fluids of both male and female rheumatoid arthritis patients, supporting the possibility of the pathogenic role for decreased androgen levels. Views on hormone replacement therapy or hormonal contraception in rheumatic diseases have been modified and in most rheumatic diseases, including rheumatoid arthritis, hormones are not prohibited. There are still controversies regarding systemic lupus; the new standpoint being that hormonal contraception is not contraindicated in women with inactive or stable active SLE, except for those with positive antiphospholipid antibodies.

Ključne riječi

estrogens; androgens; immune response; autoimmune diseases; hormonal therapy

Hrčak ID:

137773

URI

https://hrcak.srce.hr/137773

Datum izdavanja:

30.9.2014.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.031 *