Medicina, Vol. 56 No. 1, 2020.
Izvorni znanstveni članak
https://doi.org/10.21860/medflum2020_232819
The frequency of variant translocation in patients with newly diagnosed chronic myeloid leukemia (CML) in Croatian population
Željka Tkalčić Švabek
; Klinički bolnički centar Zagreb, Klinički zavod za laboratorijsku dijagnostiku, Odjel za citogenetiku, Zagreb, Hrvatska
Marina Josipović
; Opća bolnica „Dr. Josip Benčević” Slavonski Brod, Odjel za laboratorijsku dijagnostiku, Slavonski brod
Ivana Franić Šimić
; Klinički bolnički centar Zagreb, Klinički zavod za laboratorijsku dijagnostiku, Odjel za citogenetiku, Zagreb, Hrvatska
Sažetak
Aim: Chronic myeloid leukemia (CML) is characterized by a fusion of the BCR-ABL gene as the result of a reciprocal translocation of chromosomes 9 and 22 forming the Philadelphia (Ph) chromosome .Ninety percent of patients have reciprocal translocation t(9;22), while the other 5-10 % have a variant translocation that includes more chromosomes except chromosome 9 and 22. The aim of this study is to analyze the percentage of variant translocation of newly diagnosed patients with CML and the percentage of total cytogenetic response (KCgO) compared with patients having reciprocal t(9; 22). Materials and Methods: The study included bone marrow (BM) of 177 patients with newly diagnosed CML. For analysis of Ph chromosome, a karyogram was used as a conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) as a molecular cytogenetic analysis. Results: Variant translocation has been shown in 14 patients in the period of 5 years and 3 months period, while 163 patients have reciprocal translocation t(9; 22). Conclusion: The percentage of patients with variant translocation in this study agrees with the results of research in the world. There is no statistically significant difference in achieving KCgO in patients with a variant translocation t(9;22) compared to KCgO patients with reciprocal translocation.
Ključne riječi
bone marrow; chronic myelogenus leukemia; cytogenetics; Philadelphia chromosome
Hrčak ID:
232819
URI
Datum izdavanja:
1.3.2020.
Posjeta: 1.923 *