Original scientific paper
https://doi.org/10.15644/asc54/3/2
Interleukin-6 and Interleukin-10 Gene Polymorphisms in Patients with Chronic Periodontitis and Response to Treatment after 3 Years
Georgios S. Chatzopoulos
orcid.org/0000-0002-6951-8794
; Division of Periodontology, Department of Developmental and Surgical Sciences, University of Minnesota, Minneapolis, MN, USA
Aikaterini-Elisavet Doufexi
; Private practice limited to Periodontics and Implant Dentistry, Thessaloniki, Greece Privatna parodontološka i implantacijska ordinacija, Solun, Grčka; Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Greece
Sofia Zarenti
; Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Greece
Menelaos Anastasopoulos
; Department of Preventive Dentistry, Periodontology and Implant Biology, School of Dentistry, Aristotle University of Thessaloniki, Greece
Anastasia Kouvatsi
; Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, Greece
Abstract
Objective: The aim of this study was to investigate whether genetic susceptibility to chronic peri-odontitis, conferred by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele, influences the outcomes following a non-surgical periodontal therapy (NSPT)over a long period of time. Material and methods: Thirty-seven chronic periodontitis patients were divided into two groups according to genotype as susceptible (SCP) and non-susceptible (NSCP). All subjects were clinically evaluated at baseline and 3 years following NSPT. Blood samples were collected at baseline from the individuals who fulfilled the inclusion criteria. All participants received NSPT from a single periodontist who was blind to the genotype status of each patient. A statistical analysis was performed by comparing the variables between groups using the Mann-Whitney U test and between baseline and 3 years for each group using the Wilcoxon test. Results: The mean age of the population was estimated to be 47.68±8.64 years and it included 51.4% females, 48.6% smokers, and 45.9% alcohol consumers. Following a genetic analysis, 70.3% of patients were homozygous carriers of the IL-6 -572G (IL-6 SCP), and 46.0% of them were carriers, bleeding on probing, percentage of sites with 4-6mm and ≥7mm pocket depth and attachment loss) to all participants, but the treatment outcome NSCP individuals showed similar clinical parameters at baseline and at 3 years. Conclusions: Within the limitations of this 3-year prospective cohort study in Caucasians diagnosed with chronic periodontitis, individuals susceptible to periodontal disease as determined by the presence of the IL-6 -572GG genotype or the IL-10 -592A allele showed similar treatment outcome following NSPT.
Keywords
Chronic Periodontitis; Interleukin-6; Interleukin-10; Therapeutics; Genetic Polymorphism
Hrčak ID:
243987
URI
Publication date:
24.9.2020.
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