Review article

https://doi.org/10.46419/vs.52.5.11

Mineral oils in role of adjuvants in veterinary vaccines

Katja Vretenar Špigelski orcid.org/0000-0002-1720-0848 ; Croatian Veterinary Institute, Zagreb, Croatia
Eleonora Perak Junaković orcid.org/0000-0003-0630-7428 ; Croatian Veterinary Institute, Zagreb, Croatia
Ksenija Šandor orcid.org/0000-0002-8730-5282 ; Croatian Veterinary Institute, Zagreb, Croatia
Anja Vujnović orcid.org/0000-0002-8311-9407 ; Croatian Veterinary Institute, Zagreb, Croatia
Sonja Sinković orcid.org/0000-0001-6293-0842 ; Croatian Veterinary Institute, Zagreb, Croatia
Irena Žarković orcid.org/0000-0002-3263-2024 ; Croatian Veterinary Institute, Zagreb, Croatia
Dominika Fajdić orcid.org/0000-0002-3338-523X ; Croatian Veterinary Institute, Zagreb, Croatia
Svjetlana Terzić orcid.org/0000-0001-9221-285X ; Croatian Veterinary Institute, Zagreb, Croatia

Abstract

In veterinary medicine vaccines play a key role in control of animal health. With the advancement of science, not only whole microorganisms (inactivated or attenuated) are active substances in vaccines, but also vaccines containing parts of microorganisms (recombinant proteins or synthetic peptides) obtained by various advanced technologies are being developed. Thus, a higher degree of safety of the vaccine is ensured and better immunogenicity is achieved by the addition of an adjuvant. Adjuvants in the form of aluminum salts which have been in use for decades and are the most common in veterinary vaccines but adjuvants in the form of emulsions, including mineral oils, are also important. The negative side of use of mineral oils may be the occurrence of a local reaction at the site of application. Such changes may affect the slaughter value in fattening animals and the grade in competitions or exhibitions in show animals. Because of these local reactions, which can cause difficult applications due to viscosity, mineral oils are not often used as an adjuvant in vaccines intended for humans and pets, but are mainly used for vaccination of farm animals. The development of new technologies in production seeks to reduce the negative impact on animals, as well as possible reactions in people who use such vaccines, therefore, the package leaflet containing the mineral oil must contain a warning of the risks that may arise during administration and as well as instructions on how to act in the event of an accident.

Keywords

mineral oils; inactivated veterinary vaccines; adjuvants

Hrčak ID:

258275

URI

https://hrcak.srce.hr/258275

Publication date:

1.2.2021.

Article data in other languages: croatian

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