Pregledni rad

ENCEPHALOPATHY CAUSED BY THE APPLICATION OF METRONIDAZOLE

IVETA MERĆEP ; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb; Klinički bolnički centar Zagreb, Klinika za unutarnje bolesti, Zagreb, Hrvatska
MARINA TITLIĆ ; Sveučilište u Splitu, Medicinski fakultet, Split; Klinički bolnički centar Split, Klinika za neurologiju, Split, Hrvatska
ANA ĆURKOVIĆ KATIĆ ; Klinički bolnički centar Split, Klinika za neurologiju, Split, Hrvatska
ANA REPIĆ BULIČIĆ ; Klinički bolnički centar Split, Klinika za neurologiju, Split, Hrvatska
NIKOLINA FRIŠČIĆ ; Klinički bolnički centar Zagreb, Klinika za unutarnje bolesti, Zagreb, Hrvatska

Sažetak

Metronidazole is an antibiotic used for treating anaerobic bacterial and parasitic infections. A rare side effect of using this drug is encephalopathy. The most commonly observed symptoms include dysarthria, gait instability, and/or ataxia. Metronidazole induced encephalopathy should be differentiated from other possible causes of encephalopathy. Clinical picture with data on metronidazole application, as well as magnetic resonance imaging (MRI) of the brain, T2 and FLAIR sequences, neurological diagnostic procedures such as electroencephalography (EEG), laboratory tests and lumbar puncture should be performed. Typical brain MRI fi ndings in T2 and FLAIR technique show hyperintensity, which in most cases affects dentate nucleus of the cerebellum, parts of brainstem, and splenium corporis callosi. Genetic testing is sometimes required to distinguish some rare causes of encephalopathy. Neurological changes due to metronidazole application are most often reversible and vanish after metronidazole withdrawal. Use of methylprednisolone in treating this type of encephalopathy is sometimes helpful.

Ključne riječi

metronidazole; side effects; encephalopathy

Hrčak ID:

261268

URI

https://hrcak.srce.hr/261268

Datum izdavanja:

10.8.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.700 *