Izlaganje sa skupa
PSYCHOSES BY ATTACKS FROM SUBVERTED MAST CELLS: A ROLE FOR ARTERIAL INTRAMURAL FLOW BADLY STEERED BY THE NASAL GANGLIA?
Gottfried R. S. Treviranus
orcid.org/0000-0001-8859-7259
; Psychiatrische Praxis am Unitobler Campus, Berne, Switzerland
Sažetak
Mechanisms of cortical psychoses are approached by complementing big data-driven genetics and imaging with a putatively
subverted neurovascular “reverse plumbing” by arteries. The “cortical spread” of grey matter loss in schizophrenia and the midpericallosal
“congestion” in fMRI of periodic catatonia - treatable electromagnetically along arteries - are interpreted in terms of
the fastest interstitial outflow through the Cerebral IntraMural Reverse Arterial Flow-engine (CIMURAF, Treviranus 2018-19)
draining “waste” via arterio-adventitial lymphatics to the neck. Such repetitively sliding segments of CIMURAF are wrung
downstream by muscles likely steered by the neurovascular pterygopalatine ganglion. At the pericallosal artery, along its ideal long
straight segment, this likely happens diverging from the mid-callosum towards the front and the back. In the case of a convergent
inversion a mid-callosal clash will result, which is observable in psychoses as a mid-callosal high-flow-spot simultaneously with
hyper-perfusions of branches and “backwatering” of pial vessels with reactive waste - till date interpreted psycho-mathematically.
CIMURAF might also accelerate the perivascular intrusion of MCs by flushing autocrine signals (of which electro-magnetism moves
the dipoles) through a putative periadventitial counter-current. Psychoses plausible occur through tryptase-mediated attacks
operated by mast cells against oligodendrocytes` cytoskeleton (Medic 2009) and probably via complement-4 (Schizophrenia WG,
2014) against neurons. Usually MCs are essential long-lived “orchestrators” of homeostases and immune or barrier defences
interacting with nerves, immunocytes, organs, and routes. MCs after somatic programming as to “destination & destiny”
(Treviranus 2017a, 6.2., 2018) rapidly intrude also into the brain`s parenchyma, first within the lymphatics and then putatively by crossing-over to extraluminal arterial routes. MCs transverse the BBBs, while macrophages only trespass in “disease“ (Faraco et al. 2017). Both can be “subverted” by a list of microbes (and putatively blown up by COVID-19 within walls). Enuresis and MCs’ reactions to clozapine add to the interactive support from (epi-)genetics and imaging.
Ključne riječi
psychoses; Intramural Peri-Arterial Drainage; microbial subversion of mast cells; Covid-19; clozapine and enuresis
Hrčak ID:
262498
URI
Datum izdavanja:
24.3.2020.
Posjeta: 417 *