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https://doi.org/10.20471/acc.2021.60.02.12

Iodine Status and Thyroid Function in Lactating Women and Infants – a Survey in the Zagreb Area, Croatia

Marina Prpić ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Maja Franceschi ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Valentina Vidranski ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Maria Andersson ; Division of Gastroenterology and Nutrition, Zurich University Children’s Hospital, Zurich, Switzerland; Iodine Global Network, Ottawa, Ontario, Canada
Michael B. Zimmermann ; Iodine Global Network, Ottawa, Ontario, Canada; Human Nutrition Laboratory, Institute of Food, Nutrition and Health, Zurich ETH, Zurich, Switzerland
Sandra Hunziker ; Human Nutrition Laboratory, Institute of Food, Nutrition and Health, Zurich ETH, Zurich, Switzerland
Milan Milošević ; University of Zagreb, School of Medicine, Andrija Štampar School of Public Health, WHO Collaborative Centre for Occupational Health, Zagreb, Croatia
Zvonko Kusić ; Croatian Academy of Sciences and Arts, Zagreb, Croatia
Tomislav Jukić orcid.org/0000-0001-5631-164X ; Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Sažetak

Lactating women (LW) and infants have high dietary iodine requirements and are
at risk of iodine deficiency. The aim of the study was to assess iodine status and thyroid function in LW
and their breastfed infants in Zagreb, Croatia. The study included 133 LW and breastfed infant pairs.
Urinary iodine concentration (UIC) and thyroid function parameters were measured in all subjects. In
LW, breast milk iodine concentration (BMIC) was measured and iodine and salt rich food frequency
questionnaire data were collected. Results of analysis indicated that 99.2% of the LW used iodized salt
in household and 20.4% used iodine-containing vitamin and mineral supplements. Median (IQR)
UIC was 75 μg/L (19.0-180.5 μg/L) in LW and 234 μg/L (151.0-367.5 μg/L) in infants, whereas
BMIC was 121 μg/kg (87.8-170.8 μg/kg). Multivariate regression analysis revealed BMIC to be a
significant predictor of infant UIC (p<0.001). Positive correlation was recorded between LW and infant
thyroid function. This was the first study in Croatia demonstrating BMIC to be a reliable biomarker
of iodine status during lactation and predicting iodine intake in breastfed infants. The study
confirmed that mandatory salt iodization in Croatia ensured sufficient dietary iodine for LW and
optimal iodine intake for breastfed infants via breast milk.

Ključne riječi

Breastfeeding; Infants; Iodine; Thyroglobulin; Thyroid hormones

Hrčak ID:

263706

URI

https://hrcak.srce.hr/263706

Datum izdavanja:

1.6.2021.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.367 *