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IRISIN AS A PREDICTOR OF MICROALBUMINURIA IN OBESE PATIENTS WITH CORONARY ARTERY DISEASE
YULIIA KOVALOVA
orcid.org/0000-0002-6463-9861
; Department of Internal Medicine No. 2, Clinical Immunology and Allergology named after academician L.T. Malaya, Kharkiv National Medical University, Kharkiv, Ukraine
BORYS SHELEST
orcid.org/0000-0001-5528-8302
; Department of Internal and Occupational Diseases, Kharkiv National Medical University, Kharkiv, Ukraine
TETIANA RUDENKO
; Cardiology, Therapy and Nephrology Department, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
MARIIA KHVYSIUK
; Cardiology, Therapy and Nephrology Department, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
MARYNA KOLOMIIETS
; Cardiology, Therapy and Nephrology Department, Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine
Sažetak
Background. Irisin is a recently discovered protein involved in energy homeostasis and glucose metabolism, and is potentially involved in atherosclerosis, obesity, and cardiovascular diseases. The aim of the study was to investigate the irisin effect on microalbuminuria in obese patients with coronary artery disease (CAD). Methods. Sixty-four adult subjects with CAD combined with obesity (59.38% of males), mean age 59.43±10.29 years, were enrolled in the study. Control group included 30 sex- and age-matched subjects. Obese patients with CAD were divided into two groups: group 1 (n=31) without microalbuminuria, and group 2 (n=33) with microalbuminuria. The urine albumin to creatinine ratio (ACR, range 30-300 mL/
mg) indicated microalbuminuria. Specifi c enzyme-linked immunosorbent assay was used for serum irisin measurement. Results. Serum irisin concentrations were signifi cantly different in obese CAD patients with microalbuminuria 121.05 (103.07-133.19) ng/mL and those without it 130.21 (125.21-140.03) ng/mL compared to the control group 147.92 (139.04-172.55) ng/mL (p<0.001), and irisin level was signifi cantly lower in patients with microalbuminuria in comparison with normoalbuminuria (p=0.042). Univariate logistic regression analyses showed irisin to signifi cantly infl uence microalbuminuria (OR: 0.788, 95% CI 0.589-0.967, p=0.011). Multivariable logistic regression analyses revealed that serum irisin remained
a signifi cant predictor of microalbuminuria (OR: 0.857, 95% CI 0.561-0.988, p=0.044). Conclusions. Lower irisin levels are an independent predictor of microalbuminuria in patients with CAD combined with obesity. Additional larger longitudinal studies are needed to confirm these findings.
Ključne riječi
irisin; obesity; coronary artery disease; microalbuminuria; endothelial function
Hrčak ID:
273931
URI
Datum izdavanja:
16.3.2022.
Posjeta: 696 *