Skoči na glavni sadržaj

Kemija u industriji : Časopis kemičara i kemijskih inženjera Hrvatske, Vol. 71 No. 5-6, 2022.

Pregledni rad

https://doi.org/10.15255/KUI.2021.070

Renaissance of the Hofmann-Löffler-Freytag Reaction – Development of C–H Functionalisation Strategies Based on Green Chemistry Principles

Gabrijel Zubčić orcid id orcid.org/0000-0003-3264-5826 ; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb
Sofia Shkunnikova orcid id orcid.org/0000-0003-2546-0823 ; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb
Davor Šakić orcid id orcid.org/0000-0002-8871-6622 ; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb
Marijan Marijan ; Sveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet, Ante Kovačića 1, 10 000 Zagreb

Puni tekst: hrvatski pdf 1.637 Kb

str. 359-373

preuzimanja: 164

citiraj

Sažetak

Increased demand for drugs has promoted the pharmaceutical and chemical industries as the most dynamic industries of the 21st century. By using the Hofmann-Löffler-Freytag (HLF) reaction, the modification of pharmacologically active substances and biologically important compounds can be achieved in an environmentally friendly manner by highly efficient syntheses. This reaction enables the formation of new compounds according to the principles of green chemistry, without expensive metal catalysts. Numerous computational and experimental studies have shown exceptional flexibility and the possibility of optimising this method in order to increase the economy and reduce the amount of waste generated as by-products of synthetic processes. However, the mechanism of this reaction is yet to be elucidated sufficiently, and further experiments are necessary in order to determine the thermodynamic and kinetic parameters that control and guide the HLF reaction. It is necessary to determine the influence of substituents and solvents on 1,5-HAT or 1,6-HAT regioselectivity, and to recognise the mechanism responsible for switching between the radical and ionic mechanism of the reaction.




This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi

Hofmann-Löffler-Freytag reaction; green chemistry; 1,5-HAT; 1,6-HAT; regioselectivity; mechanistic switch

Hrčak ID:

277689

URI

https://hrcak.srce.hr/277689

Datum izdavanja:

15.5.2022.

Podaci na drugim jezicima: hrvatski

Posjeta: 598 *