Izvorni znanstveni članak
https://doi.org/10.15255/KUI.2021.083
Structure of Potential Dithiolopyrrolone Antibiotics Detected from the DART-ToF-MS Spectra of Saccharothrix algeriensis Extract
Noureddine Bouras
orcid.org/0000-0003-2714-5026
; Laboratoire de Biologie des Système Microbiens (LBSM), École Normale Supérieure de Kouba, Alger, Alžir
Basel F. Alrayes
; Département de Biologie, Faculté des Sciences de la Nature et de la Vie et Sciences de la Terre, Université de Ghardaıa, Ghardaïa, Alžir
Salim Mokrane
orcid.org/0000-0003-3489-3911
; Laboratoire de Biologie des Système Microbiens (LBSM), École Normale Supérieure de Kouba, Alger, Alžir
Hadj Daoud Bouras
; Département de Physique, Ecole Normale Supérieure de Laghouat, Laghouat, Alžir
Michael D. Holtz
; Field Crop Development Centre, Alberta Agriculture and Forestry, 5030 – 50 Street, Lacombe, Alberta T4L1W8, Kanada
Ahmed-Yacine Badjah-Hadj-Ahmed
; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudijska Arabija
Sažetak
Dithiolopyrrolone antibiotics, produced by the Saharan mycelial bacterium Saccharothrix algeriensis, are known for their potent biological activities. Biochemical profiling of S. algeriensis culture extract was done by direct analysis in real time and time-of-flight mass spectrometry (DART-ToF-MS). No other study on dithiolopyrrolones by this technique has been published. Eleven dithiolopyrrolone derivatives: thiolutin, butyryl-pyrrothine/iso-butyryl-pyrrothine, senecioyl-pyrrothine/tigloyl-pyrrothine, valeryl-pyrrothine/iso-valeryl-pyrrothine, 2-methyl-3-pentenyl-pyrrothine/2-hexonyl-pyrrothine, iso-hexanoyl-pyrrothine and benzoyl-pyrrothine were characterised by their exact mass measurement and the corresponding molecular formula of each compound. The obtained results confirmed that DART-ToF-MS is an appropriate confirmatory technique for powerful and rapid screening, as well as characterisation of bacterial secondary metabolites.
Ključne riječi
Saccharothrix algeriensis; direct analysis in real time; time-of-flight mass spectrometry; dithiolopyrrolone analogs; antibiotics
Hrčak ID:
280487
URI
Datum izdavanja:
18.7.2022.
Posjeta: 323 *