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DERMATOSCOPY IN PREDICTING BASAL CELL CARCINOMA MARGINS

IVANA MANOLA ; Poliklinika Manola, Zagreb, Hrvatska
ANA MATAIĆ orcid.org/0000-0001-9118-464X ; Klinički zavod za patologiju i citologiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
MILAN MILOŠEVIĆ orcid.org/0000-0001-9008-7645 ; Škola narodnog zdravlja „Andrija Štampar“, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
DANIJELA LEDIĆ DRVAR ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska; Klinika za dermatologiju i venereologiju, Klinički bolnički centar Zagreb, Zagreb
ANDREJA PETROVIĆ ; Klinički zavod za patologiju i citologiju KB Merkur, Zagreb, Hrvatska
BOŽO KRUŠLIN orcid.org/0000-0002-0480-1687 ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska; Klinički zavod za patologiju i citologiju „Ljudevit Jurak“, Klinički bolnički centar „Sestre milosrdnice“, Zagreb, Hrvatska

Sažetak

Introduction: Basal cell carcinoma (BCC) is a slow-growing epithelial tumor that rarely metastasizes, and has the rising incidence in the last decades. Complete surgical removal to reduce local recurrence is the therapy goal. Aim: To investigate the effi cacy of dermatoscopy in distinguishing superfi cial from other histopathologic BCC subtypes and in predicting the required surgical margins to reduce recurrence rate. Methods: We conducted a single-center, retrospective study in the period between January 1, 2011 and December 31, 2020. After BCC diagnosis was established, skin lesions were evaluated using dermatoscopy. After surgical excision, histopathologic analysis of the tumor and peritumoral tissue was performed by an experienced pathologist. Correlation between dermatoscopy and histopathology fi ndings were evaluated. Results: All tumors were up to 20 mm in largest diameter with head and neck being the most affected skin site (56%). There was an absolute correlation between dermatoscopy and histopathology in superfi cial BCC subtype (kappa coeffi cient 1.000; p<0.001), lower in nodular (kappa 0.847; p<0.001) and infi ltrative subtype (kappa value 0.846, p<0.001). A large majority of tumors were 1-2 mm from the inked margins (81%), belonging to pT1 category. Regarding the recurrence rate, there was no statistically signifi cant relationship with tumor size, margin or base status or tumor thickness; 8.8% of patients had recurrence in the median follow-up period of 120 months. There was a signifi cantly poorer survival period regarding recurrence in infi ltrative BCC subtype when compared to superfi cial (51 vs. 108 months; p<0.001) and nodular subtype (51 vs. 72 months, p<0.001). Conclusion: Dermatoscopic evaluation of the BCC margins could be helpful in preoperative assessment, with emphasis on inking of surgical specimen margins.

Ključne riječi

basal cell carcinoma; dermatoscopy; margins; inking

Hrčak ID:

294442

URI

https://hrcak.srce.hr/294442

Datum izdavanja:

27.2.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.133 *