Izvorni znanstveni članak
Effect of Pesticides on Wound Contraction
Željko Glavić
Ljubo Begić
Ilija Bagarić
Srećko Sabalić
Marijana Šimunović
Marta Gotovac
Sažetak
Agricultural injuries are a complex surgical problem, especially because of frequently extensive skin lesions prone to infection
and delayed healing. The aim of the study was to assess the local effect of pesticides, chemical substances widely used in
agriculture, on wound healing, especially on wound contraction. Local effects of the combined herbicide composed of atrazine
and dual (Primextra) and insecticide alphametrin (Fastac 10% SC) on primary wound healing were assessed in a bioassay
performed in 18 New Zealand white rabbits. Relative size of the wound, measured on days 0, 1, 3, 6, 9 and 12 of wounding
was analyzed by two-factor analysis of variance with repeat measurements. The activity of the process of restoration was assessed
on histopathologic preparations obtained after the last measurement. Results of the study showed the final wound contraction
to be smaller and the process of healing slower in the experimental groups of animals. Histopathology revealed defects
of epithelialization, phasic delay in healing, infiltration with eosinophilic granulocytes, and decreased density of newly
formed collagen. Pesticides were concluded to have adverse local effects on the wound, causing impairment of the mechanisms
of healing.
Ključne riječi
pesticides; wound contraction; wound healing
Hrčak ID:
27294
URI
Datum izdavanja:
4.1.2007.
Posjeta: 1.411 *