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CLINICAL AND PATHOLOGICAL PRESENTATIONS OF PATIENTS WITH HPV POSITIVE OROPHARYNGEAL CARCINOMA – A SOUTH CROATIAN STUDY
LUKA MINARIK
orcid.org/0000-0002-4867-3648
; Zavod za hitnu meticinu Zagrebačke županije, Zagreb; 2 Zavod za anatomiju, histologiju i embriologiju, Medicinski fakultet, Sveučilište u Splitu, Split, Hrvatska
BRACO BOŠKOVIĆ
; Klinika za otorinolaringologiju i kirurgiju glave i vrata, Klinički bolnički centar Split, Split, Hrvatska
ANA DUNATOV
; Klinički zavod za patologiju, forenzičku medicinu i citologiju, Klinički bolnički centar Split, Split, Hrvatska
JELENA VICULIN
; Klinika za onkologiju i radioterapiju, Klinički bolnički centar Split, Split, Hrvatska
BENJAMIN BENZON
; Zavod za anatomiju, histologiju i embriologiju, Medicinski fakultet, Sveučilište u Splitu, Split, Hrvatska
MERICA GLAVINA DURDOV
; Klinički zavod za patologiju, forenzičku medicinu i citologiju, Klinički bolnički centar Split, Split, Hrvatska
Sažetak
Objective: The objective of this study was to analyze the influence of human papilloma virus (HPV) in patients with oropharyngeal
squamous cell carcinoma (OPSCC) from southern Croatia on survival, clinical outcomes, and pathological features. Methods: We
analyzed HPV DNA presence and p16 immunohistochemistry staining in 68 formalin-fixed paraffin-embedded samples from patients diagnosed with OPSCC at the Split University Hospital Center between 2013 and 2017. Histologic features were analyzed
using a light microscope. Clinical data were retrospectively collected from patient records and analyzed for HPV status. Results:
In this study, 10.29% of patients were HPV positive (HPV+). Lymphocyte invasion was more prominent in p16 positive OPSCC.
Overall survival (OS) was better in HPV+ and p16+ patients. HPV status is a significant prognostic variable for patients from south
Croatia with OPSCC. Conclusion: HPV seems to have a minor influence on OPSCC in south Croatia in comparison to other Western European countries and the USA. Although the influence of HPV on survival was significant, traditional risk factors were more important in the carcinogenesis of OPSCC in our population.
Ključne riječi
Croatia; head and neck neoplasms; histology; human papilloma virus 16; oropharyngeal neoplasms; squamous cell carcinoma
Hrčak ID:
310005
URI
Datum izdavanja:
22.11.2023.
Posjeta: 247 *