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EPIDEMIOLOGICAL DATA ON RENAL BIOPSIES IN SOUTHERN CROATIA – A SINGLE CENTER REPORT OF 22-YEAR EXPERIENCE AT SPLIT UNIVERSITY HOSPITAL CENTER
DIJANA BORIĆ ŠKARO
; Department of Nephrology, Split University Hospital Center, Split, Croatia
NATALIJA FILIPOVIĆ
orcid.org/0000-0002-8943-4109
; Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Split, Croatia
IVO JELIČIĆ
orcid.org/0000-0001-8477-1280
; Department of Nephrology, Split University Hospital Center, Split, Croatia
MAJA MIZDRAK
orcid.org/0000-0002-2112-004X
; Department of Nephrology, Split University Hospital Center, Split, Croatia
IVANA TADIN HADJINA
; Department of Gastroenterology, Split University Hospital Center, Split, Croatia
MERICA GLAVINA DURDOV
; Department of Pathology, Split University Hospital Center, Split, Croatia; University of Split School of Medicine, Split, Croatia
MIRNA SARAGA-BABIĆ
; Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Split, Croatia
ADELA ARAPOVIĆ
; Department of Pediatrics, Split University Hospital Center, Split, Croatia
MARIJAN SARAGA
; University of Split School of Medicine, Split, Croatia; Department of Pediatrics, Split University Hospital Center, Split, Croatia
DRAGAN LJUTIĆ
; Department of Nephrology, Split University Hospital Center, Split, Croatia; University of Split School of Medicine, Split, Croatia
KATARINA VUKOJEVIĆ
orcid.org/0000-0003-2182-2890
; Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Split, Croatia
Sažetak
The Croatian Registry of Native Renal Biopsy (CRNRB) was established in 2019. Thus, in this study, we present retrospective
data on kidney biopsies in adult patients performed at the Split University Hospital Center from 1994 to 2019 before the CRNRB
establishment. The aim of the study was to show epidemiological data on glomerular diseases in southern Croatia in order to compare them with others and provide data for the establishment of the CRNRB. During the study period, 110 patients (mean age 46.6±15.4, age range 17-76 years), 68 men and 42 women, underwent renal biopsy at the Department of Internal Medicine,
Split University Hospital Center in Split. Data on age, sex, serum creatinine, urinalysis, daily proteinuria, and complications after
biopsy were collected and related to indication for biopsy and pathological diagnosis. Light and immunofluorescence analysis
was supplemented by electron microscopy in 63.5% of cases. Indications for biopsy were nephrotic syndrome (64.5%), asymptomatic urinary tract abnormalities (12.7%), and acute renal failure of unknown cause (9.1%). The most common diagnosis was IgA nephropathy (IgAN) (20.9%), the prevalence of which decreased during the study period. IgAN was followed by focal segmental glomerulosclerosis (FSGS) (19.1%), membranous nephropathy (13.6%), lupus nephritis and minimal change disease (8.2%), crescentic glomerulonephritis (5.4%), embranoproliferative glomerulonephritis (4.5%), mesangial proliferative glomerulonephritis (3.6%), amyloidosis (3.6%), Henoch-Schönlein nephritis (3.6%), and Alport syndrome (2.7%). Other forms of glomerular diseases were rarely found. IgAN was most frequently found in men (26.5%) and FSGS in women (21.4%). These data can be included in the historical epidemiological observation of glomerular diseases in Southeastern Europe. The guidelines for performing biopsies need to be constantly updated to improve preventive and therapeutic strategies.
Ključne riječi
biopsy-proven renal disease; epidemiology; glomerulonephritis; renal biopsy; renal pathology; registry
Hrčak ID:
310549
URI
Datum izdavanja:
22.11.2023.
Posjeta: 166 *