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Kemija u industriji : Časopis kemičara i kemijskih inženjera Hrvatske, Vol. 73 No. 5-6, 2024.

Izvorni znanstveni članak

https://doi.org/10.15255/KUI.2023.037

Correlation between Optical Characteristics of Orodispersible Films with Selected Process Parameters Supported by FTIR Analysis

Ognjenka Rahić orcid id orcid.org/0000-0003-0183-1124 ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina *
Amina Tucak-Smajić ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina
Merima Šahinović ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina
Belma Imamović orcid id orcid.org/0000-0002-2500-1419 ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedre za analitiku lijekova, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina
Lamija Hindija ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina
Jasmina Hadžiabdić ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina
Edina Vranić ; Univerzitet u Sarajevu, Farmaceutski fakultet, Katedra za farmaceutsku tehnologiju, Zmaja od Bosne 8, 71 000 Sarajevo, Bosna i Hercegovina

* Dopisni autor.

Puni tekst: engleski pdf 678 Kb

str. 215-220

preuzimanja: 100

citiraj

Sažetak

Paediatric and geriatric populations, as well as other special patient populations with swallowing problems, require patient-tailored dosage forms. One promising dosage form for these specific populations is orodispersible films.
When preparing orodispersible films using sodium carboxymethyl cellulose as the film-forming polymer and glycerine as the plasticizer, it is essential to determine the optimal mixing time and mixing speed of the casting solution to achieve the desired transparency/opacity of the orodispersible films. In this paper, the primary focus is on mixing time and mixing speed, and determining how these two parameters can influence optical characteristics. All tested parameters are supported by FTIR analysis. The obtained results show that either a mixing speed of 7000 rpm on a high-shear mixer for 15 min or a mixing speed of 9000 rpm for 5 min can produce films with optimal optical characteristics.

Ključne riječi

orodisperisble films; sodium carboxymethyl cellulose; glycerine; optical characteristics; FTIR

Hrčak ID:

316818

URI

https://hrcak.srce.hr/316818

Datum izdavanja:

14.5.2024.

Podaci na drugim jezicima: hrvatski

Posjeta: 430 *