Izvorni znanstveni članak
PROGNOSTIC VALUE OF HEMOGLOBIN TO RED CELL DISTRIBUTION WIDTH RATIO FOR PATIENTS WITH HODGKIN LYMPHOMA
NIKA PUŠELJIĆ
; Objedinjeni hitni bolnički prijem, Klinički bolnički centar Osijek, Hrvatska
VLATKA PERIŠA
; Zavod za hematologiju, Klinika za unutarnje bolesti, Klinički bolnički centar Osijek, Hrvatska; Medicinski fakultet Osijek, Sveučilište Josipa Jurja Strossmayera, Osijek, Hrvatska
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* Dopisni autor.
Sažetak
Aim: To examine whether the value of hemoglobin to red blood cell distribution width ratio (HRR) at the time of diagnosis of Hodgkin lymphoma (HL) was an independent prognostic factor of overall survival (OS), event-free survival (EFS), and response to therapy, as well as to test the interrelations of HRR with demographic, clinical, and laboratory characteristics.
Materials and methods: This research was designed as a retrospective cohort study of patients with histologically verified HL,
diagnosed at the Clinical Hospital Center Osijek in the period from April 2005 to August 2022.
Results: A total of 83 subjects, with a median age of 36 years, ranging from 19 to 82, participated in the research. A significant
difference in HRR was found depending on the outcome of treatment, OS, and EFS. A lower HRR was associated with a worse
therapeutic response, a higher risk of relapse, and other worse prognostic factors. A positive correlation of HRR with middle
corpuscular volume, number of erythrocytes, and albumin level was found, and a negative correlation with erythrocyte sedimentation rate, number of platelets, and C-reactive protein concentration.
Conclusion: Lower HRR was associated with unfavorable clinical and pathological characteristics of HL. There is a good potential
for HRR as a prognostic marker and it should be applied with other known biochemical and hematological markers.
Ključne riječi
hemoglobin; Hodgkin lymphoma; red blood cell distribution width; hemoglobin to red blood cell distribution width ratio; survival
Hrčak ID:
331217
URI
Datum izdavanja:
16.5.2025.
Posjeta: 355 *