Medicina Fluminensis, Vol. 61 No. 3, 2025.
Pregledni rad
https://doi.org/10.21860/medflum2025_332189
Glycans as Possible Biomarkers in Diagnosis of Neurodegenerative Diseases
Marin Tota
; University of Rijeka, Faculty of Medicine, Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Rijeka, Croatia
Ana Blagaić
; Clinical Hospital Centre Rijeka, Department of Anaesthesiology and Intensive Care, Rijeka, Croatia
*
David Bonifačić
; Clinical Hospital Center Rijeka, Department of Neurology, Rijeka, Croatia; University of Rijeka, Faculty of Medicine, Department of Neurology, Rijeka, Croatia
* Dopisni autor.
Sažetak
Glycosylation is one of the most significant and common protein modifications.Many clinical biopharmaceuticals today are also glycosylated. The resulting glycoproteinsmay have one or more glycan structures attached through N- or O-glycosidic bonds. Theprofiles of glycosylation can change with aging, as well as in conditions like Alzheimer’s,Parkinson’s, and other neurological disorders. This means that many glycoproteins couldserve as useful biomarkers for diagnosing diseases and tracking their progression. However,the role of glycosylation in the central nervous system is not well understood, even thoughit is quite prevalent. Future research will focus on creating detailed glycoprofiles fromdifferent body fluids and tissues and analysing this enormous amount of information byusing conventional methods with the help of artificial intelligence lately.
Ključne riječi
biomarkers; glycosylation; neurodegenerative diseases; polysaccharides
Hrčak ID:
332189
URI
Datum izdavanja:
1.9.2025.
Posjeta: 376 *