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Libri Oncologici : Croatian Journal of Oncology, Vol. 53 No. 1, 2025.

Review article

https://doi.org/10.20471/LO.2025.53.01.02

Metabolizam karcinoma mozga

Lana Manojlović orcid id orcid.org/0009-0001-3173-4248 ; School of Medicine, University of Zagreb, Zagreb, Croatia
Martina Periša orcid id orcid.org/0000-0001-6854-5080 ; School of Medicine, University of Zagreb, Zagreb, Croatia
Darko Orešković ; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia
Marina Raguž orcid id orcid.org/0000-0001-9203-7254 ; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, and School of Medicine, Catholic University of Croatia, Zagreb, Croatia
Darko Chudy ; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia and Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience, School of Medicine, Croatian Institute for Brain Research, University of Zagreb, Zagreb, Croatia
Tonko Marinović orcid id orcid.org/0009-0006-5513-6994 ; Department of Neurosurgery, Clinical Hospital Dubrava, Zagreb, Croatia and Department of Neurology and Neurosurgery, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

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Abstract

Maligni tumori mozga predstavljaju ozbiljan zdravstveni problem, kako kod djece, tako i kod odraslih, te su često neizlječivi. Metabolizam tumora nedavno se istaknuo kao obećavajuća meta za otkrivanje novih mogućnosti u liječenju raka. Maligni tumori mozga snažno ovise o glikolizi za dobivanje energije, za koju pretežno koriste glukozu i glutamin, za razliku od zdravih moždanih stanica koje prvenstveno koriste ketonska tijela u uvjetima smanjene opskrbe glukozom. Kao metabolički poremećaj koji uključuje deregulaciju glikolize i staničnog disanja, postoji nada da bi se tumor mozga mogao barem dijelom kontrolirati promjenama u metaboličkom okruženju. Cilj ovog osvrta jest ispitati metaboličke promjene u tumorima mozga i sažeti najnovijja saznanja o određenim metaboličkim procesima tumorigeneze, kao i potencijalne terapiske pristupe povezane s njima.

Keywords

tumori mozga; metabolizam raka; metabolički putevi; metabolička terapija

Hrčak ID:

334405

URI

https://hrcak.srce.hr/334405

Publication date:

21.8.2025.

Article data in other languages: english

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