Izvorni znanstveni članak
Resistin Gene Promoter -420C>G (rs1862513) and +299 G>A (rs3745367) Polymorphisms in Psoriasis
Nazli Dizen-Namdar
orcid.org/0000-0002-9116-5489
; Kutahya Health Sciences University, Faculty of Medicine, Department of Dermatology, Kutahya, Turkey;
*
Raziye Akcilar
; Kutahya Health Sciences University, Faculty of Medicine, Department of Physiology, Kutahya, Turkey
Fulya Yukcu
; Kutahya Health Sciences University, Faculty of Medicine, Department of Biophysics, Kutahya, Turkey
Selve Arslan-Utku
; Kutahya Health Sciences University, Faculty of Medicine, Department of Dermatology, Kutahya, Turkey;
Zeynep Bayat-Sarioglu
; Kutahya Dumlupinar University, Faculty of Arts and Sciences, Department of Biochemistry, Kutahya, Turkey
* Dopisni autor.
Sažetak
Background: The pro-inflammatory adipokine resistin is known to be related
to obesity, insulin resistance, and inflammation. Resistin’s significance in the
etiology of inflammatory illnesses, such as psoriasis, is explored herein. We
examined the link between resistin gene polymorphisms (-420 C>G and +299
G>A) and psoriasis in the Turkish population.
Methods: In this study, we examined 107 patients with psoriasis and 103
healthy controls. Resistin -420 C>G (rs1862513) and +299 G>A (rs3745367)
gene polymorphisms were determined by polymerase chain reaction-restric-
tion fragment length polymorphism (PCR-RFLP).
Results: In patients with psoriasis, the frequency of the resistin -420 CG gen-
otype was meaningfully lower than in the controls. In comparison with the
controls, the resistin +299 GA genotype and A allele frequencies were signifi-
cantly higher. The Resistin -420 CG genotype significantly reduced the risk of
psoriasis incidence, while the resistin +299 GA genotype and A allele were
found to be associated with a higher risk of psoriasis.
Conclusions: In the Turkish community, resistin gene polymorphisms at -420
C>G and +299 G>A may exert an important influence on psoriasis etiology
and susceptibility.
Ključne riječi
psoriasis; resistin gene polymorphism; rs1862513; rs3745367
Hrčak ID:
335574
URI
Datum izdavanja:
1.2.2024.
Posjeta: 106 *