Izvorni znanstveni članak

https://doi.org/10.20471/acc.2025.64.01.12

Efficacy of Nasal Irrigation with Isotonic and Hypertonic Solutions after Endoscopic Sinus Surgery for Chronic Rhinosinusitis with Nasal Polyposis

Ana Penezić ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Catholic University, School of Medicine, Zagreb, Croatia *
Livije Kalogjera ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Marko Velimir Grgić ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Goran Geber ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dentistry University of Zagreb, Zagreb, Croatia
Dejan Tomljenović ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dentistry University of Zagreb, Zagreb, Croatia
Konstantinos Alevizopoulos ; Research and Development Department, Gerolymatos International S.A., Athens, Greece
Tomislav Baudoin ; Department of Otorhinolaryngology, Head and Neck Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

* Dopisni autor.

Sažetak

Endoscopic sinus surgery (ESS) is often involved in the treatment of patients with
chronic rhinosinusitis with nasal polyposis (CRSwNP). Nasal irrigation after ESS is recommended to
improve healing and nasal symptoms in these patients. This study compared the efficacy of nasal irrigation
with either an isotonic solution of 0.9% NaCl or a hypertonic solution of 2.3% NaCl comprising algal
extracts. This was a randomized cohort study that included patients with CRSwNP after ESS who used
isotonic solution and hypertonic 2.3% solution enriched with algal extracts (Undaria pinnatifida and Spirulina
platensis). Patients filled out the total nasal symptom score (TNSS) questionnaire on visual analog
scale of five symptoms, i.e., nasal obstruction, nasal secretion and/or postnasal discharge, sense of pressure
in the face, headache, loss of the sense of smell preoperatively, and on postoperative days 7 and 14. Endoscopic
Lund-Kennedy (LK) score was also recorded. The study included 54 patients with CRSwNP that
had undergone ESS, mean age 49.5 years. There were 53.7% of male patients. Thirty (55.56%) patients
had other comorbidities such as allergic rhinitis, allergy to food, or/and asthma. Five (9.25%) patients had
CRSwNP, asthma and allergy to nonsteroidal anti-inflammatory drugs. TNSS improved after 7 and 14
days in both groups; greater improvement of TNSS and LK score was observed in the group of patients
that used hypertonic solution with algae, but it did not reach statistical significance. Improvement in
particular symptoms was also recorded in the hypertonic solution group both on postoperative days 7 and
14, especially of sneezing and itching. The results of this study confirmed therapeutic benefits of nasal irrigation
in CRSwNP patients following ESS. Patients who used hypertonic solution enriched with algae
experienced greater improvement in sneezing and itching over the 14-day period.

Ključne riječi

Nasal polyposis; Endoscopic sinus surgery; Nasal irrigation; Hypertonic solution; Chronic rhinosinusitis; Seaweed extract

Hrčak ID:

335734

URI

https://hrcak.srce.hr/335734

Datum izdavanja:

31.3.2025.

Podaci na drugim jezicima: hrvatski

Posjeta: 462 *