Review article

https://doi.org/10.20471/acc.2025.64.01.13

Vitamin D in Patients with Inflammatory Skin Diseases

Liborija Lugović-Mihić orcid.org/0000-0001-7494-5742 ; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia *
Maja Tolušić Levak ; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sara Špičić ; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Vedrana Bulat ; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ana Brkić ; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ana Šešerko ; Department of Gynecology and Obstetrics, Zagreb University Hospital Center, Zagreb, Croatia.

* Corresponding author.

Abstract

In search for the ways to cure and improve skin condition of patients with inflammatory
skin diseases, vitamin D supplementation has been shown to be useful, primarily due to its effects on
a number of skin functions, e.g., keratinocyte proliferation, differentiation and apoptosis, maintenance of
the epidermal barrier, and regulation of immune processes in the skin, among others. Vitamin D is essential
for good general health and healthy skin, but deficiency can occur due to various factors that result in
increased time spent indoors and limited sunlight exposure, such as geography (place of residence) and
genetic factors. Although some results are inconsistent, previous research indicates that multiple inflammatory
skin diseases can be affected by vitamin D deficiency, particularly atopic dermatitis, but also other
inflammatory skin diseases. There is also evidence for an association between vitamin D deficiency and
the risk of worsening of skin diseases such as psoriasis, chronic urticaria, contact dermatitis, etc. For these
and several other inflammatory skin diseases, most research suggests that patients benefit from vitamin
D supplementation.

Keywords

Vitamin D; Vitamin D deficiency; Atopic dermatitis; Psoriasis; Chronic urticaria; Contact dermatitis

Hrčak ID:

335735

URI

https://hrcak.srce.hr/335735

Publication date:

31.3.2025.

Article data in other languages: croatian

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