Professional paper

https://doi.org/10.21860/medflum2025_336671

Outcomes of Surgical Treatment for High- and Low-Risk Prostate Cancer: A Retrospective Study

Ivona Antončić ; Klinički bolnički centar Rijeka, Klinika za tumore, Rijeka, Hrvatska; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska *
Ivona Mićović ; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska; Klinički bolnički centar Rijeka, Klinički zavod za patologiju i citologiju, Rijeka, Hrvatska
Christophe Štemberger ; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska; Klinički bolnički centar Rijeka, Klinički zavod za patologiju i citologiju, Rijeka, Hrvatska
Dag Zahirović ; Klinički bolnički centar Rijeka, Klinika za tumore, Rijeka, Hrvatska
Iva Skočilić ; Klinički bolnički centar Rijeka, Klinika za tumore, Rijeka, Hrvatska; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska
Kristian Krpina ; Klinički bolnički centar Rijeka, Klinika za urologiju, Rijeka, Hrvatska
Dorian Srok ; Klinički bolnički centar Rijeka, Klinika za urologiju, Rijeka, Hrvatska
Dean Markić ; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska; Klinički bolnički centar Rijeka, Klinika za urologiju, Rijeka, Hrvatska

* Corresponding author.

Abstract

Aim: To analyze and compare clinical-pathological characteristics and five-year treatment outcomes of low-risk and high-risk patients with prostate cancer treated with radical prostatectomy between 2014 and 2018. Patients and methods: A retrospective cohort study included 240 patients with histologically confirmed prostate cancer treated with radical prostatectomy at University Hospital Centre Rijeka. Patients were stratified into low-risk (117 patients) and high-risk groups (123 patients) according to European Association of Urology (EAU) guidelines. Demographic, clinical, and pathological characteristics and five-year survival were analyzed. Results: Five-year survival rates were 92.31% for the low-risk group and 78.05% for the high-risk group (P = 0.004). Biochemical recurrence occurred in 21% of low-risk and 61% of high-risk patients. Metastatic disease developed in 0.9% of low-risk and 15% of high-risk patients. Conclusions: Risk stratification according to EAU guidelines enables precise differentiation of treatment outcomes. Low-risk patients have an excellent prognosis, while high-risk patients achieve satisfactory survival with multimodal approach. Key challenges in the future will include the implementation of advanced imaging diagnostics and genomic analyses in order to define risk categories even more precisely, thereby enabling a more personalized selection of therapy and improving oncological outcomes, while simultaneously optimizing the accessibility of these methods in resource-limited settings.

Keywords

carcinoma; prostatectomy; risk assessment; treatment outcome

Hrčak ID:

336671

URI

https://hrcak.srce.hr/336671

Publication date:

1.12.2025.

Article data in other languages: croatian

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