Original scientific paper

https://doi.org/10.20471/acc.2025.64.02.13

Non-HDL-C Might Predict Major Adverse Cardiovascular Event Occurrence in Statin-Naïve Patients Following First-Time Myocardial Infarction – a Preliminary Report

Lamija Ferhatbegović ; Department of Internal Diseases and Hemodialysis, Zenica University Hospital, Zenica, Bosnia and Herzegovina *
Farid Ljuca ; Tuzla Medical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina
Zumreta Kušljugić ; Tuzla Medical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina
Katarina Kovačević ; Department of Internal Diseases, Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Denis Mršić ; Department of Internal Diseases, Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Sabina Kušljugić ; Department of Ophthalmology, Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Mirsad Selimović ; Department of Internal Diseases, Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina

* Corresponding author.

Abstract

The aim of this study was to examine the effect of the lipid parameter non-high-density
lipoprotein cholesterol (non-HDL-C) on the occurrence of major cardiovascular event (MACE)
in patients after first-time ST-elevation myocardial infarction (STEMI) treated with primary percutaneous
intervention (pPCI) and implantation of drug-eluting stent (DES). Seventy-eight patients
(54 male and 24 female, median age 58.62±11.14 years) with the diagnosis of first-time STEMI who
were treated with pPCI with DES implantation in the period from January 2018 until January 2020
were included in the study. Patients were followed for two years of the intervention for the occurrence
of MACE and its association with baseline non-HDL-C, as well as total cholesterol, LDL-C,
HDL-C and triglycerides. During 2-year follow-up, 20 (25.6%) patients had MACE. There was no
significant difference in baseline parameters such as age, hypertension, presence of diabetes mellitus,
and post-interventional use of statin therapy between patients with and without MACE. The levels
of baseline lipid parameters were significantly higher in patients who experienced MACE, as follows:
total cholesterol (p=0.009), LDL-C (p=0.028) and non-HDL-C (p=0.007). Pearson χ2-test showed
that both non-HDL-C and LDL-C were significant predictors of MACE occurrence during 2-year
follow-up, but non-HDL-C had a more significant correlation than LDL-C (p=0.007 vs. p=0.028).
Our initial report shows that baseline non-HDL-C was a more significant predictor of the occurrence
of MACE after first-time STEMI than LDL-C, which reflects the importance of the residual risk of
MACE occurrence while enabling identification and close monitoring of high-risk patients.

Keywords

Acute myocardial infarction; Major adverse cardiovascular event, Non-high-density lipoprotein cholesterol; Low-density lipoprotein cholesterol

Hrčak ID:

337596

URI

https://hrcak.srce.hr/337596

Publication date:

30.6.2025.

Article data in other languages: croatian

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