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Acta clinica Croatica, Vol. 64. No. 2, 2025.

Izvorni znanstveni članak

https://doi.org/10.20471/acc.2025.64.02.18

Expression of Connexin-40 and Interleukin 6 Genes in Patients with Atrial Fibrillation

Saima Sharif ; Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Hafsa Ijaz ; Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Saira Rafaqat orcid id orcid.org/0000-0001-7177-5602 ; Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Shabina Waris ; Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Shagufta Naz orcid id orcid.org/0000-0001-9699-5193 ; Department of Zoology, Lahore College for Women University, Lahore, Pakistan
Aleksandra Klisic orcid id orcid.org/0000-0001-7870-0996 ; University of Montenegro, Faculty of Medicine, Podgorica, Montenegro; Center for Laboratory Diagnostics, Primary Health Care Center, Podgorica, Montenegro *

* Dopisni autor.

Puni tekst: engleski pdf 241 Kb

str. 345-352

preuzimanja: 96

citiraj

Sažetak

Atrial fibrillation (AF) is the outcome of the rapid onset of abnormal electrical
impulses in the atria. These impulses prevent the heart natural pacemaker, which normally controls the
heart beat, from doing its job. The heart rate becomes highly asymmetric. The purpose of this case-control
study was to determine the role of the connexin-40 (Cx-40) and interleukin-6 (IL-6) gene expression
in patients suffering from AF in Pakistan. There were 200 subjects included in this study. The subjects
were categorized into two groups as control and AF groups (n=100 each). RNA separated from blood
was used for analysis of the Cx-40 and IL-6 gene expression by real-time polymerase chain reaction. The
Cx-40 gene expression profile was increased 10.2-fold in AF subjects as compared to 1.9-fold in control
group. The IL-6 gene expression profile was decreased 1.5-fold in AF group as compared to 6.1-fold
in control group. Results of the study suggest that development of AF in the Pakistani population was
linked to the increased expression of Cx-40 gene and lower expression of IL-6 gene.

Ključne riječi

Atrial fibrillation; Connexin-40; Interleukin-6; Gene expression

Hrčak ID:

337641

URI

https://hrcak.srce.hr/337641

Datum izdavanja:

30.6.2025.

Podaci na drugim jezicima: hrvatski

Posjeta: 269 *