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Acta clinica Croatica, Vol. 64. No. 2, 2025.

Original scientific paper

https://doi.org/10.20471/acc.2025.64.02.21

Effect of Platelet Rich Fibrin on Wound Healing Time after Revascularization

Mijo Mravičić orcid id orcid.org/0009-0009-3642-903X ; Department of Vascular Surgery, Merkur University Hospital, Zagreb, Croatia *
Ana Adžić-Kapitanović ; Department of Surgery, Merkur University Hospital, Zagreb, Croatia
Andrej Razumić ; Department of Quality, Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia
Marta Bakšić ; Department of Vascular Surgery, Merkur University Hospital, Zagreb, Croatia
Vedran Pažur ; Department of Vascular Surgery, Merkur University Hospital, Zagreb, Croatia
Tena Magovac ; Department of Vascular Surgery, Merkur University Hospital, Zagreb, Croatia
Marko Granić ; Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Zagreb University Hospital Center, Zagreb, Croatia

* Corresponding author.

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Abstract

One of the most common diseases in vascular surgery is peripheral arterial disease,
the last stage of which is critical limb ischemia. It is characterized by rest pain or tissue loss. In most
cases, after revascularization, and due to gangrenous changes, it is necessary to perform amputation of a
part of the lower limb. After amputation, the wound is bandaged with dressings. In conducting this pilot
study, some patients were bandaged with platelet rich fibrin (PRF) in combination with dressings, while
the others were treated only with dressings. PRF is a biologic material that is received from blood of the
patient. All patients included in the trial had at least 2 out of 3 traversable blood vessels in the lower leg
before treatment and underwent femoropopliteal bridging with prosthesis. Patients treated with PRF
after revascularization had an average of 5 weeks of wound healing, in contrast to patients treated only
with dressings, whose mean wound healing was 8.5 weeks and a proportion of these patients ended up
with an extended amputation level. After the study, it is concluded that this type of treatment can be
safely used in the treatment of vascular pathology.

Keywords

Peripheral arterial disease; Critical limb ischemia; Platelet rich fibrin; Amputation

Hrčak ID:

337960

URI

https://hrcak.srce.hr/337960

Publication date:

30.6.2025.

Article data in other languages: croatian

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