Acta clinica Croatica, Vol. 64. No. 2, 2025.
Review article
https://doi.org/10.20471/acc.2025.64.02.22
Intraocular Pressure of Premature Newborns – a Systematic Review with Meta-Analysis
Kalina Trifonova
; Department of Ophthalmology, University Hospital, Stara Zagora, Bulgaria
Kiril Slaveykov
; Department of Ophthalmology, University Hospital, Stara Zagora, Bulgaria
*
Hristo Mumdzhiev
; Department of Neonatology, University Hospital, Stara Zagora, Bulgaria
* Corresponding author.
Abstract
The intraocular pressure (IOP) ranges of premature newborns are not the same as
those in full-term newborns and adult population. The exact ranges and causes, however, differ depending
on the measurement techniques used and analysis. Our study aimed to summarize and analyze
available information in the up-to-date literature concerning IOP values in premature newborns. We
performed a systematic literature review with meta-analysis. Our research showed the mean IOP in
premature newborns to range from 10 to 29 mmHg according to different authors, and its mean values
were higher in premature compared to full-term newborns. The most commonly analyzed factor that
probably affected IOP measurement was central corneal thickness. Longitudinal studies showed that
IOP and central corneal thickness declined with maturation of the newborn and both factors were
probably correlated. Additional studies with larger sample sizes and better differentiated sample groups
need to be performed.
Keywords
Preterm infants; Infants; Central corneal thickness; Intraocular pressure
Hrčak ID:
337961
URI
Publication date:
30.6.2025.
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