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Acta clinica Croatica, Vol. 64. No. 2, 2025.

Book review

https://doi.org/10.20471/acc.2025.64.02.24

Clear Cell Variant of Ameloblastic Carcinoma of the Maxilla: A Case Report and Review of Differential Diagnostic and Therapeutic Approach

Luka Manojlović orcid id orcid.org/0000-0001-6054-8244 ; Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia *
Daniel Jerković ; Department of Oral and Maxillofacial Surgery, Dubrava University Hospital, Zagreb, Croatia
Davor Brajdić ; Department of Oral and Maxillofacial Surgery, Dubrava University Hospital, Zagreb, Croatia; School of Dentistry, University of Zagreb, Zagreb, Croatia
Predrag Knežević ; Department of Oral and Maxillofacial Surgery, Dubrava University Hospital, Zagreb, Croatia; School of Dentistry, University of Zagreb, Zagreb, Croatia
Spomenka Manojlović ; Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

* Corresponding author.

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Abstract

Ameloblastic carcinoma is a rare malignant epithelial tumor, mostly affecting the
mandible. Maxillary ameloblastic carcinoma is even more uncommon and its clear cell variant has
been exceedingly rarely described. Because clear cell lesions of jaw bones are both rare and diagnostically
challenging, the incidence of the tumor, as well as the criteria for classification are not precisely
defined. Differential diagnosis includes a variety of benign or malignant tumors of odontogenic
and salivary gland origin, as well as metastatic tumors. Diagnostic dilemma extends to therapeutic
approach. Treatment modalities are still debated. The present case report discusses the clinical and
histologic differential diagnosis of clear cell variant of an aggressive maxillary ameloblastic carcinoma
which was successfully treated with preoperative radiation therapy, followed by surgical excision of the
residual lesion and reconstruction of the maxilla.

Keywords

Ameloblastic; Clear-cell; Odontogenic; Carcinoma; Pathology; Radiotherapy

Hrčak ID:

337963

URI

https://hrcak.srce.hr/337963

Publication date:

30.6.2025.

Article data in other languages: croatian

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