Reumatizam, Vol. 72 No. Supp 1, 2025.
Stručni rad
https://doi.org/10.33004/reumatizam-supp-72-1-1
“Sjőgren’s Syndrome – Evaluation of Diagnosis and Therapy in the Light of Artificial Intelligence and Transhumanism – Quo vadis?“
Jasenka Markeljević
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* Dopisni autor.
Sažetak
“Sjőgren’s Syndrome – Evaluation of Diagnosis and Therapy in the Light of Artificial Intelligence and Transhumanism – Quo vadis?“mune system, acting harmoniously like a symphony directed by the expression of genes that regulate immunomodulation mediated by the neuro-endocrine-humoral system (NEH) controls the activation of autoimmunity. Disturbed NEH homeostasis associated with endogenous and exogenous factors in genetically predisposed individuals leads to the activation of systemic and local autoimmunity, morphological and/or functional damage to mucous membranes, tissues and organs, due to complex interactions of the serotonergic and endocrine systems, cellular and humoral immunity, pro-inflammatory cytokines and neuropeptides. The contemporary paradigm in the evaluation of local and systemic autoimmunity based on the reductionist approach of singling out individual “triggers” is opposed by a comprehensive approach complementary to the heterogeneous nature of SjS. The clinical picture of SjS varies from a local, glandular form, like dryness of all mucous membranes, usually the eye and oral cavity, to a systemic extraglandular manifestation in the form of involvement of the interstitium and tissues of other organ systems. New scientific knowledge in the field of nanotechnology and proteogenomics has stimulated the rise of Predictive, Preventive, Personalized and Participatory Medicine, so-called P4 medicine, enabling more precise diagnosis and prediction of the outcome of SjS. In light of the “mosaic of autoimmunity”, evolution into another AIB, accelerated atherogenesis, cardiovascular risk and potential malignant alteration, SjS requires a multidisciplinary approach in the evaluation of diagnostic and therapeutic protocols. The implementation of artificial intelligence (AI) in the field of medicine has contributed to a more objective and precise identification of morphological and histopathological characteristics of salivary glands and immunological parameters, which are crucial for the diagnosis and classification of SjS, disease prognosis and individualization
of specific therapy. By shaping diagnostic and therapeutic algorithms in the wake of transhumanism that seeks to transform the human essence, the application of AI compels us to apply clear ethical guidelines in the context
of cost/benefit analysis of P4 medicine, i.e., potential discrimination against patients. Quo vadis? It is a question to
which we find the answer in the conscientious, ethical and professional application of scientific achievements for the
benefit of our patients, the present and future of our civilization.
Ključne riječi
Sjoegren’ syndrome, pathophysiology, classification, development
Hrčak ID:
339081
URI
Datum izdavanja:
12.11.2025.
Posjeta: 304 *