Izvorni znanstveni članak
https://doi.org/10.5599/jese.2841
Electrochemical determination of paracetamol and chlorpheniramine using AuNPs-rGO modified glassy carbon electrode
Huynh Van Chung
; University of Sciences, Hue University, Hue City, Vietnam and Faculty of Pharmacy, Buon Ma Thuot Medical University, Buon Ma Thuot City, Vietnam
Nguyen Hai Phong
; University of Sciences, Hue University, Hue City, Vietnam
Dao Thi Cam Minh
; University of Medicine and Pharmacy, Hue University, Hue City, Vietnam
Ho Xuan Anh Vu
; University of Sciences, Hue University, Hue City, Vietnam
Pham Khac Lieu
; University of Sciences, Hue University, Hue City, Vietnam
Nguyen Thi Thanh Huyen
; Institute of Research and Development, Duy Tan University, Danang City, Vietnam
Trinh Ngoc Dat
; University of Education and Science, The University of Danang, Danang City, Vietnam
Doan Manh Dung
; Institute of Biotechnology and Environment, Tay Nguyen University, Buon Ma Thuot, Vietnam
Do Thi Duyen
; Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi city, Vietnam
Dinh Quang Khieu
; University of Sciences, Hue University, Hue City, Vietnam
*
* Dopisni autor.
Sažetak
One of the significant durability challenges is the corrosion of reinforced concrete. A gold nanoparticle/reduced graphene oxide modified glassy carbon electrode (AuNPs-rGO-GCE) was fabricated using an electrochemical reduction method for the simultaneous determination of paracetamol (PAR) and chlorpheniramine maleate (CPM). AuNPs-rGO modified GC electrodes were prepared through direct electrochemical reduction of GO to rGO, followed by direct reduction of Au ions to Au on the rGO matrix. X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectra, Raman spectroscopy, energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy, electrochemical impedance spectroscopy, and X-ray photoelectron spectroscopy characterized the resulting AuNPs-rGO. It was found that AuNPs around 15.4 nm were highly dispersed on the rGO. The modification of GCE by AuNPs-rGO accelerates the electron transfer process and increases the conductivity of the electrode. The AuNPs-rGO modified electrode was used to simultaneously determine PAR and CPM using the square-wave anodic stripping voltammetry (SQW-ASV) method. Under suitable experimental conditions, the SQW-ASV method using AuNPs-rGO-GCE showed a wide linear range from 23.7 to 140.0 µM for PAR and from 7.5 to 54.0 µM for CPM. The limit of detection of PAR and CPM was 7.12 and 2.54 µM, respectively. The proposed SQW-ASV method was applied to analyze PAR and CPM in samples of herbal medicine simultaneously, and the results were compared with those of high-performance liquid chromatography, with no statistical difference.
Ključne riječi
Drug sensors; square-wave anodic stripping voltammetry; ochemically reduced graphene oxide; herbal medicine
Hrčak ID:
339941
URI
Datum izdavanja:
25.8.2025.
Posjeta: 0 *