Original scientific paper
https://doi.org/10.26332/e83fpk63
Diagnostic Accuracy of Atypical Glandular Cells in the Pap Test
Valentina Jambrišak
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
*
Marija Perić
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; University Hospital Osijek, Croatia
Kristina Kralik
orcid.org/0000-0002-4481-6365
; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
* Corresponding author.
Abstract
Objectives: The focus of this study was to determine how much the new type of categorization “Zagreb 2016.”, that excluded a certain number of glandular findings as reactive and negative, affected the frequency of Pap Test cytological samples marked as atypical glandular lesions (NOS, probably intraepithelial lesion and probably invasive lesion). In addition, we wanted to determine the diagnostic value of category atypical glandular cells (AGC) for each of the three subtypes of this category.
Participants and methods: This research included respondents who underwent pathohistological examination of the endometrial or endocervical biopsy tissue sample in Clinical Institute for Pathology Clinical Hospital Center Osijek in time frame from year 2018. to 2022. Respondants previously conducted a cytological examination of the same sample and were marked as atypical glandular cells (AGC).
Results: In range from year 2018. to 2022. a decrease in number of patients marked with AGC was noticed. AGC-NOS Pap smear finding has limited diagnostic value for predicting histopathologically confirmed changes. Although there is a significant association, diagnostic concordance is low. In contrast, the AGC – favour invasive lesion category shows high specificity and high positive and negative predictive value.
Conclusion: The research showed that using the classification “Zagreb 2016”, which excluded the category atypical glandular cells of undetermined significance, and introduced the category endocervical epithelium reactive and irritated, for epithelium showing only reactive changes, the number of unnecessarily diagnosed and processed patients was reduced. Results of this study confirmed that the diagnostic categories AGC-NOS and AGC – intraepithelial lesion have limited diagnostic value, while the diagnostic category AGC – invasive lesion has significantly better diagnostic features in the prediction of pathohistologically confirmed lesions compared to previous two AGC subgroups
Keywords
AGC –favour intraepithelial lesion; AGC –favour invasive lesion; AGC-NOS; atypical glandular cells; diagnostic accuracy
Hrčak ID:
342714
URI
Publication date:
29.12.2025.
Visits: 268 *