Stručni rad
https://doi.org/10.46419/cvj.57.3.2
High-mortality outbreak of Yersinia pseudotuberculosis infection in a guinea pig herd: a case report
Dinko Novosel
; Laboratory for Pathology, Department of Pathological Morphology, Croatian Veterinary Institute, 10000 Zagreb, Croatia
*
Gordan Kompes
; Laboratory for General Bacteriology and Mycology, Department of Bacteriology and Parasitology, Croatian Veterinary Institute, 10000 Zagreb, Croatia
Boris Habrun
orcid.org/0009-0002-9688-026X
; Laboratory for General Bacteriology and Mycology, Department of Bacteriology and Parasitology, Croatian Veterinary Institute, 10000 Zagreb, Croatia
Andreja Jungić
; Laboratory for Rabies and General Virology, Department of Virology, Croatian Veterinary Institute, 10000 Zagreb, Croatia
* Dopisni autor.
Sažetak
Yersinia pseudotuberculosis caused a fulminant outbreak in a Croatian breeding colony of 84 guinea pigs, in which 80 animals (95%) died within 72 hours after abrupt food refusal and marked lethargy, without diarrhoea. Seven freshly dead animals were examined. At necropsy, 2–5 mm, white-yellow nodules were found distributed in the liver, spleen, lungs, mesenteric lymph nodes and partly also in the small intestine. Aerobic culture of these organs on Columbia blood agar (28°C, 24–48 h) revealed pure growth of Y. pseudotuberculosis. Histology showed well demarcated necro-pyogranulomatous lesions with central bacterial colonies, margins of neutrophils and a peripheral coat of macrophages and few lymphocytes. Immunohistochemistry confirmed abundant lysozyme-positive macrophages and few CD3-positive T and CD79α-positive B cells, indicating a predominantly innate response. This case report emphasises the extreme lethality and rapid progression of guinea pig yersiniosis and highlights its zoonotic potential.
Ključne riječi
Yersinia pseudotuberculosis; guinea pig; histopathology; immunohistochemistry
Hrčak ID:
345267
URI
Datum izdavanja:
15.5.2026.
Posjeta: 519 *