Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats

Erkekoğlu, Pınar; Balcı-Özyurt, Aylin; Dilara Zeybek, Naciye; Tezel-Yalçın, Hülya; Yaman, Ünzile; Yildiztekin, Gizem; Aydın-Dilsiz, Sevtap; Kızılgün, Murat; İşcan, Evin; Batur, Tuğçe; Öztürk, Mehmet; Han Edebal, Oğuz; Başaran, Nurşen; Koçer-Gumusel, Belma

doi:10.2478/aiht-2026-77-4027

Arhiv za higijenu rada i toksikologiju, Vol. 77 No. 2, 2026.

Izvorni znanstveni članak

https://doi.org/10.2478/aiht-2026-77-4027

Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats

Pınar Erkekoğlu orcid.org/0000-0003-4713-7672 ; Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Sıhhiye, Ankara, Turkey
Aylin Balcı-Özyurt ; Bahçeşehir University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey
Naciye Dilara Zeybek ; Hacettepe University Faculty of Medicine, Department of Histology and Embryology, Sıhhiye, Ankara, Turkey
Hülya Tezel-Yalçın ; Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Sıhhiye, Ankara, Turkey
Ünzile Yaman ; İzmir Katip Çelebi University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Izmir, Turkey
Gizem Yildiztekin ; Erzincan Binali Yıldırım University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Erzincan, Turkey
Sevtap Aydın-Dilsiz ; Hacettepe University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Sıhhiye, Ankara, Turkey
Murat Kızılgün ; University of Health Sciences, Gülhane Faculty of Medicine, Ankara, Turkey
Evin İşcan ; Dokuz Eylul University, Izmir Biomedicine and Genome Centre, Izmir, Turkey
Tuğçe Batur ; Dokuz Eylul University, Izmir Biomedicine and Genome Centre, Izmir, Turkey
Mehmet Öztürk ; Izmir Tinaztepe University Galen Research Centre, Izmir, Turkey
Oğuz Han Edebal ; Near East University Hospital, Department of Biochemistry, Nicosia, Cyprus
Nurşen Başaran ; Başkent University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
Belma Koçer-Gumusel ; Okan University Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey

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APA 6th Edition

Erkekoğlu, P., Balcı-Özyurt, A., Dilara Zeybek, N., Tezel-Yalçın, H., Yaman, Ü., Yildiztekin, G., ... Koçer-Gumusel, B. (2026). Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats. Arhiv za higijenu rada i toksikologiju, 77 (2), 102-113. https://doi.org/10.2478/aiht-2026-77-4027

MLA 8th Edition

Erkekoğlu, Pınar, et al. "Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats." Arhiv za higijenu rada i toksikologiju, vol. 77, br. 2, 2026, str. 102-113. https://doi.org/10.2478/aiht-2026-77-4027. Citirano 21.07.2026.

Chicago 17th Edition

Erkekoğlu, Pınar, Aylin Balcı-Özyurt, Naciye Dilara Zeybek, Hülya Tezel-Yalçın, Ünzile Yaman, Gizem Yildiztekin, Sevtap Aydın-Dilsiz, et al. "Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats." Arhiv za higijenu rada i toksikologiju 77, br. 2 (2026): 102-113. https://doi.org/10.2478/aiht-2026-77-4027

Harvard

Erkekoğlu, P., et al. (2026). 'Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats', Arhiv za higijenu rada i toksikologiju, 77(2), str. 102-113. https://doi.org/10.2478/aiht-2026-77-4027

Vancouver

Erkekoğlu P, Balcı-Özyurt A, Dilara Zeybek N, Tezel-Yalçın H, Yaman Ü, Yildiztekin G i sur. Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats. Arh Hig Rada Toksikol. [Internet]. 2026 [pristupljeno 21.07.2026.];77(2):102-113. https://doi.org/10.2478/aiht-2026-77-4027

IEEE

P. Erkekoğlu, et al., "Testicular toxicity of Aroclor 1254 in selenium-deficient and selenium-supplemented rats", Arhiv za higijenu rada i toksikologiju, vol.77, br. 2, str. 102-113, 2026. [Online]. https://doi.org/10.2478/aiht-2026-77-4027

Sažetak

Aroclor 1254 (A1254) is a mixture of polychlorinated biphenyl (PCB) congeners known to induce testicular toxicity through oxidative stress, apoptosis, and hormonal disruption. Selenium (Se), an essential trace element for male reproduction, contributes to antioxidant defence, DNA repair, and spermatogenesis. Given the worldwide prevalence of Se deficiency and its potential impact on reproductive health, this study investigated the effects of A1254 exposure on testicular function in Sprague-Dawley rats with different Se status. Rats assigned to the Se-deficient group were receiving a ≤0.05 mg/kg Se diet, while those assigned to the Se-supplemented group were receiving 1 mg/kg Se for five weeks. A1254-treated groups were receiving 10 mg/kg/day of A1254 by oral gavage for 15 consecutive days. A1254 exposure caused significant reductions in testis weight, sperm count, motility, and plasma testosterone levels, accompanied by extensive germ cell apoptosis and enhanced lipid and protein oxidation. Total antioxidant capacity also dropped significantly, confirming redox imbalance in A1254-exposed testes. These adverse effects were substantially exacerbated in the Se-deficient group, whereas Se supplementation ameliorated but did not fully prevent histological and biochemical changes induced by A1254. Our findings demonstrate that Se plays a crucial protective role against PCB-associated testicular injury, primarily by mitigating oxidative stress and apoptotic pathways. However, Se supplementation alone may not completely counteract the reproductive toxicity caused by persistent environmental contaminants such as A1254.