Medicina, Vol. 45 No. 3, 2009.
Pregledni rad
Unveiling the mechanisms of breast cancer pathogenesis by proteomics methods
Ivana Ratkaj
; Insti tut “Ruđer Bošković”, Zavod za molekularnu medicinu, Laboratorij za sistemsku biomedicinu,, Zagreb, Hrvatska
Sandra Kraljević Pavelić
; Odjel biotehnologije, Sveučilište u Rijeci, Rijeka, Hrvatska
Sažetak
Breast cancer is a complex and heterogenic disease. Classical molecular medical
approaches cannot be successfully used to completely understand its pathogenesis. In additi
on, fi nding new biological markers that would help in early detecti on and creati on of guided
and specifi c therapy is crucial for the future breast cancer management. The results of
breast cancer research in combinati on with those obtained by large scale methods that examine
the expression status of genes and proteins, have pointed to an important molecule,
namely the human growth hormone (hGH), as a major player in the pathogenesis of breast
cancer. It acts through the autocrine regulati on system where the acti vati on of Pax-5 gene
has been recently confi rmed as well. A large number of new biomarkers, like HOXA1, CHOP
SH3GLB1, casein kinase, p53, annexin XI, CDC25C, eIF-4E, MAP kinase 7, 14-3-3e, galecti n-1,
annexin-5, annexin-1, LDH-B, GST-pi, acti n, vimenti n, HSP70, CK18, moesin, SH3GLB1, SUB1,
SND1 i TRIM28, osteoponti n and osteonecti n, have been recently identi fi ed as well.
Ključne riječi
breast cancer; molecular medicine; protein profile; proteomics
Hrčak ID:
43669
URI
Datum izdavanja:
1.9.2009.
Posjeta: 2.096 *