Professional paper

Bullous Oral Eruptions Caused by Azithromycin

Božana Lončar ; Department of Oral Medicine, School of Dental medicine University of Zagreb, Zagreb, Croatia
Marinka Mravak-Stipetić orcid.org/0000-0001-8845-8603 ; Department of Oral Medicine, School of Dental medicine University of Zagreb, Zagreb, Croatia
Mihaela Skerlev ; University Clinic for Dermatology and Venereology, School of Medicine University of Zagreb, Croatia
Marinka Baričević ; Department of Oral Medicine, School of Dental medicine University of Zagreb, Zagreb, Croatia
Ksenija MAKAR AUŠPERGER ; University Clinical Hospital Zagreb, Croatia

Abstract

Macrolides are considered the safest group of antibiotics, with a very low prevalence of allergic reactions (0.4-3%). We present a case report of a young patient who developed bullous eruption on buccal mucosa and lips after ingestion of the third dose of azithromycin. After taking steroid therapy the lesions started to regress, but on the fourth day a new bullous eruption appeared on labial mucosa with lower intensity. This could be explained by the fact that azithromycin has a long plasma half-life and is detectable in neutrophil lysates 28 days after the last dose, which may be related to a higher risk of adverse effects. According to our knowledge and from the available
literature. This is the first described case of oral eruption after azithromycin treatment. In spite of the fact that azithromycin remains one of the best tolerated macrolides, potentially severe adverse reactions may sometimes occur.

Keywords

Macrolides; Azithromycin; Hypersensitivity; Mouth Mucosa; Blister

Hrčak ID:

69080

URI

https://hrcak.srce.hr/69080

Publication date:

15.6.2011.

Article data in other languages: croatian

Visits: 3.386 *