Review article

Toxicological aspects of anabolics in food of animal origin

Jelka Pleadin ; Croatian Veterinary Institute, Laboratory for Analytical Chemistry, Savska 143, 10000 Zagreb, Croatia
Nina Perši ; Croatian Veterinary Institute, Laboratory for Analytical Chemistry, Savska 143, 10000 Zagreb, Croatia
B. Antolović ; Faculty of Food Technology and Biotechnology, Laboratory for Toxicology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
B. Šimić ; Faculty of Food Technology and Biotechnology, Laboratory for Toxicology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia
Ivana Kmetić ; Faculty of Food Technology and Biotechnology, Laboratory for Toxicology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia

Abstract

Because of the profitability of the meat production in the livestock industry there were many cases of abuse of different substances with anabolic effect - stilbenes, stilbene derivatives, their salts and esters, antithyroid agents, natural and synthetic hormones sterodini, lactones of resorcylic acid and beta-agonists. Mode of action of substances with anabolic effect in the body differs in these groups of substances, and results in increased nitrogen retention, protein synthesis and breakdown of fat. Although the mechanisms of action are different and can be direct or indirect, use of anabolic steroids results in the same final effect, i.e. higher growth in animal breeding and better organoleptic properties of meat. Toxicological studies showed that the use of anabolic steroids on animals has resulted in numerous toxic effects on human health, considering it to be accumulated in animal tissue, which is further used in human nutrition. More cases of abuse of anabolic steroids in the world has led to significant adverse consequences for the health of consumers. Therefore, the use of substances with anabolic effect of livestock production is prohibited and must be monitored under the prescribed legislation and systematic monitoring and application of specific and selective analytical methods to determine very low concentrations of residues of such substances in various matrices.

Keywords

anabolics; toxicological aspects; food of animal origin

Hrčak ID:

70919

URI

https://hrcak.srce.hr/70919

Publication date:

15.7.2011.

Article data in other languages: croatian

Visits: 4.148 *