Review article
FUSARIUM MONILIFORME AND ITS MYCOTOXINS FUMONISINS WITH CANCERPROMOTING ACTIVITY
Danica Ramljak
; Hrvatski Veterinarski Institut, Centar za peradarstvo, Zagreb, Republika Hrvatska
Abstract
Fumonisins, recently discovered metabolites of Fusarium moniliforme Sheldon, occuring naturally in infected corn and other cereals are an area of growing concern in many countries. Presently, it seems that the economic and health risk of other mycotoxins is far below the significans of potent tumor promoter fumonisin B₁. These compounds are involved in incidence of equine leukoencephalomalacia (ELEM), porcine pulmonary edema (PPE), disease problems in poultry, hepatocarcinoma in rats and possibly esophageal carcinoma (EG) in humans. Fumonisins are significant problem because F. moniliforme in corn is widespread, naturally they occur in ppm range, and their mode of action is unique. They interfere with sphingolipid biosynthesis by specifically inhibiting an enzyme sphinganine-N-acyl transferase. Because of this, the activity of secondar messanger system in the cells is affected.
Keywords
Hrčak ID:
164763
URI
Publication date:
27.2.1993.
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