Original scientific paper

https://doi.org/10.20471/acc.2018.57.03.11

Association of Circadian Rhythm with Myocardial Infarction

Ivana Škrlec orcid.org/0000-0003-1842-930X ; Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Biology and Chemistry, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osije
Jakov Milić orcid.org/0000-0003-2543-2857 ; Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Marija Heffer orcid.org/0000-0001-6770-7359 ; Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Robert Steiner orcid.org/0000-0003-2250-9855 ; Division of Cardiovascular Diseases and Intensive Care, Department of Internal Medicine, Osijek University Hospital Centre, Osijek, Croatia
Borut Peterlin ; Clinical Institute of Medical Genetics, University Medical Center Ljubljana, Ljubljana, Slovenia
Jasenka Wagner orcid.org/0000-0002-1126-7523 ; Department of Medical Biology and Genetics, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Abstract

Cardiovascular diseases are the world’s leading cause of death. Human physiologic activities and state during illness are under the control of circadian rhythm. The aim of the study was to determine the potential association of chronotype and daytime sleepiness with susceptibility to myocardial infarction. We conducted a case-control study on 200 patients hospitalized due to myocardial infarction and 200 healthy controls. Systematic information on the past and present medical history was obtained from all participants. Chronotype was assessed using the Morningness-Eveningness Questionnaire (MEQ), and daytime sleepiness was assessed by the Epworth Sleepiness Scale (ESS). The mean age of the study population was 64±13 years, and 54.5% were male. There was no significant difference in MEQ (58.88±6.52 vs. 58.46±7.78, p=0.601) or ESS (5 (interquartile range, IQR 4-7.5) vs. 6 (IQR 3-8), p=0.912) score between patients and controls. Nevertheless, we found statistically significant differences related to risk factors for cardiovascular diseases, such as hypertension, dyslipidemia, and diabetes mellitus. However, there was no association of MEQ and ESS score with myocardial infarction in the study population.

Keywords

Cardiovascular diseases; Circadian rhythm; Myocardial infarction; Cause of death; Croatia

Hrčak ID:

216141

URI

https://hrcak.srce.hr/216141

Publication date:

1.9.2018.

Article data in other languages: croatian

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